Abstract：Brain tumor is one of the most challenging diseases in treatment. Although surgery and multimodal adjuvant therapy serve to the treatment of this disease, treating brain cancer still remains as a challenge. Due to the non-specificity and the potentially toxic of drugs and the blood–brain barrier, the efficiency of drug in treating brain cancer is relatively low, and therefore nanoparticles become an alternative treatment forbrain cancer. During the past decades, there have been great developments in the area of brain tumor treatment adopting brain tumor-targeted method. For example, the nanocarriers can simultaneously carry out specific detection, treatment, and follow-up monitoring of the tumor. New treatment strategies with nanotechnology have some important advantages, for example decreased toxicity and improved therapeutic effect. In this paper, the classification of glioma, the limitations of treating glioma, and how to target glioma using nanoparticles are summarized in detail.
扈丹丹 刘肖莹 李明慧 彭海生▲. 纳米技术治疗脑胶质瘤的研究进展[J]. 中国医药导报, 2018, 15(12): 25-27.
HU Dandan LIU Xiaoying LI Minghui PENG Haisheng▲. Advances of nanotechnology in treatment of gliomas. 中国医药导报, 2018, 15(12): 25-27.
[1] Saenz del Burgo L，Hernandez RM，Orive G， et al. Nanotherapeutic approaches for brain cancer management [J]. Nanomedicine：Nanotechnology，Biology，and Medicine，2014，10（5）：905-919.
[2] Marie SK，Shinjo SM. Metabolism and brain cancer [J]. Clinics （Sao Paulo），2011，66（Suppl 1）：33-43.
[3] Bhojani MS，Van Dort M，Rehemtulla A，et al. Targeted imaging and therapy of brain cancer using theranostic nanoparticles [J]. Molecular Pharmaceutics，2010，7 （6）：1921-1929.
[4] Orive G，Ali OA，Anitua E，et al. Biomaterial-based technologies for brain anti-cancer therapeutics and imaging [J]. Biochimicaet Biophysica Acta，2010，1806（1）：96-107.
[5] Xu HL，ZhuGe DL，Chen PP，et al. Silk fibroin nanoparticles dyeing indocyanine green for imaging-guided photo-thermal therapy of glioblastoma [J]. Drug Delivery，2018， 25 （1）：364-375.
[6] Gao X，Jin W. The emerging role of tumor-suppressive microRNA-218 in targeting glioblastoma stemness [J]. Cancer Letters，2014，353（1）：25-31.
[7] Bredlau AL，Dixit S，Chen C，et al. Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma [J]. Current neuropharmacology，2017，15（1）：104-115.
[8] Xie Z，Shen Q，Xie C，et al. Retro-inverso bradykinin opens the door of blood-brain tumor barrier for nanocarriers in glioma treatment [J]. Cancer Letters，2015，369（1）：144-151.
[9] Zhang F，Mastorakos P，Mishra MK，et al. Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers [J]. Biomaterials，2015，52：507-516.
[10] Kim SS，Harford JB，Pirollo KF，et al. Effective treatment of glioblastoma requires crossing the blood-brain barrier and targeting tumors including cancer stem cells：the promise of nanomedicine [J]. Biochemical and Biophysical Research Communications，2015，468 （3）：485-489.
[11] Su B，Wang R，Xie Z，et al. Effect of retro-inverso isomer of bradykinin on size-dependent penetration of blood-brain tumor barrier [J]. Small，2018，14（7）. doi: 10. 1002/smll.201702331
[12] Yue PJ，He L，Qiu SW，et al. OX26/CTX-conjugated PEGylated liposome as a dual-targeting gene delivery system for brain glioma [J]. Molecular Cancer，2014，13（7）：191.
[13] Zong T，Mei L，Gao H，et al. Synergistic dual-ligand doxorubicin liposomes improve targeting and therapeutic efficacy of brain glioma in animals [J]. Molecular Pharmaceutics，2014，11（7）：2346-57.
[14] Miller T，Hill A，Uezguen S，et al. Analysis of immediate stress mechanisms upon injection of polymeric micelles and related colloidal drug carriers： implications on drug targeting [J]. Biomacromolecules，2012，13（6）：1707-1718.
[15] Bi Y，Liu L，Lu Y，et al. T7 Peptide-Functionalized PEG-PLGA micelles loaded with carmustine for targeting therapy of glioma [J]. ACS Appl Mater Interfaces，2016. [Epub ahead of print]
[16] Li J，Yang H，Zhang Y，et al. Choline derivate-modified doxorubicin loaded micelle for glioma therapy [J]. ACS Applied Materials & Interfaces，2015，7：21589-21601.
[17] Hu J，Hu K，Cheng Y. Tailoring the dendrimer core for efficient gene delivery [J]. Acta Biomaterialia，2016，35：1-11.
[18] Xu L，Zhang H，Wu Y. Dendrimer advances for the central nervous system delivery of therapeutics [J]. ACS Chemical Neuroscience，2014，5：2-13.
[19] Liu P，Huang Z，Chen Z，et al. Silver nanoparticles： a novel radiation sensitizer for glioma[J]. Nanoscale，2013， 5（23）：11829-11836.
[20] Li Y，He H，Jia X，Lu WL，et al. A dual-targeting nanocarrier based on poly（amidoamine） dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas [J]. Biomaterials，2012，33（15）：3899-3908.
[21] Brunetti V，Bouchet LM，Strumia MC. Nanoparticle-cored dendrimers： functional hybrid nanocomposites as a new platform for drug delivery systems [J]. Nanoscale，2015，7（9）：3808-3816.
[22] Zheng M，Wang S，Liu Z，et al. Development of temozolomide coated nano zinc oxide for reversing the resistance of malignant glioma stem cells [J]. Materials Science & Engineering C，Materials For Biological Applications，2018，83：44-50.
[23] Xu HL，Mao KL，Huang YP，et al. Glioma-targeted superparamagnetic iron oxide nanoparticles as drug-carrying vehicles for theranostic effects [J]. Nanoscale，2016，8（29）：14222-14236.
[24] Kumar D，Saini N，Jain N，et al. Gold nanoparticles：an era in bionanotechnology [J]. Expert Opinion on Drug Delivery，2013，10：397-409.
[25] Kodiha M，Wang YM，Hutter E，et al. Off to the organelles-killing cancer cells with targeted gold nanoparticles [J]. Theranostics，2015，5（4）：357-370.
[26] Dixit S，Novak T，Miller K，et al. Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors [J]. Nanoscale，2015，7（5）：1782-1790.
2018, Vol. 15 
京公网安备 11010502046598号