Abstract：Objective To investigate the characteristics and risk factors of mixed infection of Mycoplasma Pneumoniae Pneumonia (MPP) in children. Methods Six hundred and fifteen MPP children hospitalized in Hebei Children’s Hospital from June 2016 to June 2018 were selected. Blood routine, C-reactive protein (CRP), Chlamydia/Mycoplasma IgM and sputum bacterial culture were performed in all patients. Results Among 615 children with MPP, 489 cases were in single infection group and 126 cases in mixed infection group. In mixed infection group, 72 cases in mixed virus group, 33 cases in mixed bacteria group, 21 cases in mixed Chlamydia group. There were significant differences in age, fever > 10 days and extrapulmonary complications among four groups (P < 0.05). There was no significant difference in gender and wheezing between single infection group and mixed infection groups (P > 0.05). There were significant differences in WBC, NEU and CRP among single infection group and mixed virus group, mixed bacteria group, mixed Chlamydia group (P < 0.01). The levels of WBC and CRP in mixed bacteria group were higher than those in single infection group (P < 0.05), and NEU level in mixed virus group was lower than that in single infection group (P < 0.05). Multivariate logistic analysis showed that age (OR = 0.732, P < 0.01) was a protective factor for mixed virus infection, and extrapulmonary complication (OR = 1.429, P < 0.05) was independent risk factor for mixed virus infection. Age (OR = 0.548, P < 0.01) was a protective factor for mixed bacterial infection. Fever > 10 days (OR = 3.593, P < 0.05) and WBC (OR = 2.593, P < 0.05) were independent risk factors for mixed bacterial infection. Age (OR = 3.392, P < 0.01) was an independent risk factor for mixed Chlamydia infection. Conclusion The detection rate of MPP mixed infection is lower in this area. The younger the age is, the higher the detection rate of MPP mixed infection is. The main pathogen of mixed infection is virus, followed by bacterial infection. The children are mainly mixed virus and bacterial infection. The older children should be alert to the mixed Chlamydia infection. The length of fever and the increase of WBC should be paid attention to bacterial infection.
2020, Vol. 17 
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