Progress of gastrointestinal motility effects on prevention and treatment in obesity with insulin resistance
WANG Wenyan1,2 LIANG Fengxia2
1.Department of Acupuncture-Moxibustion, Wuhan Hospital of Traditional Chinese Medicine, Hubei Province, Wuhan 430014, China;
2.College of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430061, China
Abstract：Abnormal gastrointestinal motility is an important pathological factor of obesity with insulin resistance. Abnormal gastrointestinal motility not only make the body excessive intake of energy, but also can produce the intestinal inflammation, affect information exchanges of brain-gut axis, then reduce insulin sensitivity, and reduce energy consumption relatively, which eventually lead to imbalances in the body′s energy metabolism. Therefore, it may be a new approach to prevent and treat insulin-resistant obesity to set about gastrointestinal motility and develop treatment for various factors affecting gastrointestinal motility, such as inflammation, intestinal flora and enteric nervous system.
王文炎1,2 梁凤霞2. 胃肠动力对胰岛素抵抗肥胖防治的影响进展[J]. 中国医药导报, 2020, 17(30): 49-52.
WANG Wenyan1,2 LIANG Fengxia2. Progress of gastrointestinal motility effects on prevention and treatment in obesity with insulin resistance. 中国医药导报, 2020, 17(30): 49-52.
[1] Ng M，Fleming T，Robinson M，et al. Global，regional，and national prevalence of overweight and obesity in children and adults during 1980-2013：a systematic analysis for the Global Burden of Disease Study 2013 [J]. Lancet，2014， 384（9945）：766-781.
[2] Hernandez EA，Kahl S，Seelig A，et al. Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance [J]. J Clin Invest，2017，127（2）：695-708.
[3] Miron I，Dumitrascu DL. GASTROINTESTINAL MOTILITY DISORDERS IN OBESITY [J]. Acta Endocrinol（Buchar），2019，15（4）：497-504.
[4] Gallagher TK，Geoghegan JG，Baird AW，et al. Implications of altered gastrointestinal motility in obesity [J]. Obes Surg，2007，17（10）：1399-1407.
[5] Gil-Cardoso K，Gines I，Pinent M，et al. Effects of flavonoids on intestinal inflammation，barrier integrity and changes in gut microbiota during diet-induced obesity [J]. Nutr Res Rev，2016，29（2）：234-248.
[6] Scheithauer TP，Dallinga-Thie GM，de Vos WM，et al. Causality of small and large intestinal microbiota in weight regulation and insulin resistance [J]. Mol Metab，2016，5（9）：759-770.
[7] Wang J，Li D，Wang P，et al. Ginger prevents obesity through regulation of energy metabolism and activation of browning in high-fat diet-induced obese mice [J]. J Nutr Biochem，2019，70：105-115.
[8] Ge X，Ding C，Zhao W，et al. Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility [J]. J Transl Med，2017，15（1）：13.
[9] Fu XY，Li Z，Zhang N，et al. Effects of gastrointestinal motility on obesity [J]. Nutr Metab（Lond），2014，11（1）：3.
[10] Mushref MA，Srinivasan S. Effect of high fat-diet and obesity on gastrointestinal motility [J]. Ann Transl Med，2013，1（2）：14.
[11] Ge H，Li X，Weiszmann J，et al. Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids [J]. Endocrinology，2008，149（9）：4519-4526.
[12] Karra E，Chandarana K，Batterham RL. The role of peptide YY in appetite regulation and obesity [J]. J Physiol，2009，587（1）：19-25.
[13] Arora S，Anubhuti. Role of neuropeptides in appetite regulation and obesity--a review [J]. Neuropeptides，2006， 40（6）：375-401.
[14] Zhang J，Sha W，Zhu H，et al. Blunted Peripheral and Central Responses to Gastric Mechanical and Electrical Stimulations in Diet-induced Obese Rats [J]. J Neurogastroenterol Motil，2013，19（4）：454-466.
[15] Li S，Chen JD. Pulse Width-Dependent Effects of Intestinal Electrical Stimulation for Obesity：Role of Gastrointestinal Motility and Hormones [J]. Obes Surg，2017，27（1）：70-77.
[16] Sun Y，Chen J. Rimonabant，gastrointestinal motility and obesity [J]. Curr Neuropharmacol，2012，10（3）：212-218.
[17] Lakhan SE，Kirchgessner A. Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction [J]. J Transl Med，2011，9：202.
[18] Inoue Y，Fukui H，Xu X，et al. Colonic M1 macrophage is associated with the prolongation of gastrointestinal motility and obesity in mice treated with vancomycin [J]. Mol Med Rep，2019，19（4）：2591-2598.
[19] Schéle E，Grahnemo L，Anesten F，et al. The Gut Microbiota Reduces Leptin Sensitivity and the Expression of the Obesity-Suppressing Neuropeptides Proglucagon（Gcg）and Brain-Derived Neurotrophic Factor（Bdnf）in the Central Nervous System [J]. Endocrinology，2013，154（10）：3643-3651.
[20] Bauer PV，Hamr SC，Duca FA. Regulation of energy balance by a gut-brain axis and involvement of the gut microbiota [J]. Cell Mol Life Sci，2016，73（4）：737-755.
[21] Heyman-Lindén L，Kotowska D，Sand E，et al. Lingonberries alter the gut microbiota and prevent low-grade inflammation in high-fat diet fed mice [J]. Food Nutr Res，2016，60（1）：29993.
[22] Jiang T，Gao X，Wu C，et al. Apple-Derived Pectin Modulates Gut Microbiota，Improves Gut Barrier Function，and Attenuates Metabolic Endotoxemia in Rats with Diet-Induced Obesity [J]. Nutrients，2016，8（3）：126.
[23] 于涛，赵利娜，陈其奎.脑肠肽与功能性消化不良[J].现代消化及介入诊疗，2012（4）：241-245.
[24] 王欢，黄永坤，刘梅.胃肠激素与胃肠道功能及疾病的关系[J].医学综述，2013，19（15）：2735-2738.
[25] De Silva A，Bloom SR. Gut Hormones and Appetite Control：A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity [J]. Gut Liver，2012，6（1）：10-20.
[26] Hameed S，Dhillo WS，Bloom SR. Gut hormones and appetite control [J]. Oral Dis，2009，15（1）：18-26.
[27] Choi YD，Sung TS，Kim HJ，et al. Increased 5-hydroxytryptamine mediates post-inflammatory visceral hypersensitivity via the 5-hydroxytryptamine 3 receptor in rats [J]. Dig Dis Sci，2008，53（11）：2909-2916.
[28] 王深皓，董蕾，李路，等.5-HT4受体对人消化间期小肠运动调控及其机制研究[J].胃肠病学和肝病学杂志，2014，23（3）：311-314.
[29] 王深皓，董蕾，李路，等.5-HT4受体激动剂对肠易激综合征患者消化间期运动及胃肠激素的影响[J].西安交通大学学报：医学版，2014，35（2）：254-257.
[30] Chesta J，Defilippi C，Defilippi C. Abnormalities in proximal small bowel motility in patients with cirrhosis [J]. Hepatology，1993，17（5）：828-832.
[31] 陈晓理.抑制肠运动对胰腺炎时细菌移位的影响[J].中华实验外科杂志，1996，13（6）：367-368.
[32] 陈海龙，裴德凯，王冬梅，等.多器官功能不全综合征时肠道细菌微生态学改变的实验研究[J].中国微生态学杂志，1999（1）：24-26.
[33] Collins SM，Bercik P. Gut microbiota：Intestinal bacteria influence brain activity in healthy humans [J]. Nat Rev Gastroenterol Hepatol，2013，10（6）：326-327.
[34] Collins SM，Bercik P. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease [J]. Gastroenterology，2009，136（6）：2003-2014.
[35] Collins SM，Surette M，Bercik P. The interplay between the intestinal microbiota and the brain [J]. Nat Rev Microbiol，2012，10（11）：735-742.
[36] 徐芬，梁凤霞，陈瑞，等.标本配穴电针对胰岛素抵抗大鼠胰岛素敏感性及骨骼肌SIRT1蛋白表达的影响[J].中医杂志，2014，55（4）：328-332.
[37] 陈丽.电针调控下丘脑SIRT1/NF-κB信号通路改善ZDF大鼠胰岛素抵抗的机制研究[D].武汉：湖北中医药大学，2016.
[38] 武欢，梁凤霞，陈邦国，等.电针对胰岛素抵抗肥胖大鼠炎性反应和肠道屏障的影响[J].中国针灸，2019，39（11）：1199-1204.
[39] 黄琪.电针调控SIRT1/NF-κB炎性信号通路改善胰岛素抵抗肥胖的表观遗传学机制研究[D].武汉：湖北中医药大学，2019.
[40] 王雅媛，梁凤霞，黄琪，等.肠道菌群——治疗肥胖胰岛素抵抗的新靶点[J].华中科技大学学报：医学版，2019， 48（6）：751-754.
2020, Vol. 17 
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