Banxia Baizhu Tianma Decoction combined with western medicine in the treatment of vertebrobasilar ischemic vertigo：a meta-analysis and sequential analysis
XIE Huanglie1 ZHENG Chaoyang2 ZHU Wei3 WEN Junmao4 LIU Hanqing5 TAO Wenxiang1
1.The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510403, China;
2.Department of Cardiology, Guangdong Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510030, China;
3.Key Laboratory of Syndrome Clinical Research, Guangdong Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510003, China;
4.the First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510403, China;
5.Department of Cardiology, Guangzhou Integrated Chinese and Western Medicine Hospital, Guangdong Province, Guangzhou 510800, China
Abstract：Objective To systematically evaluate the clinical efficacy of Banxia Baizhu Tianma Decoction combined with Western medicine on vertebrobasilar ischemic vertigo (VBIV). Methods PubMed database, Cochrane Library database, EMbase database, CBM database, CNKI database, VIP database, and WangFang database were searched to screen clinical study about Banxia Baizhu Tianma Decoction combined with traditional Western medicine in the treatment of VBIV, and the search time was from the establishment to October, 2019. Meta analysis and trial sequential analysis of included studies were carried out using Stata 13.0 software. Results A total of 28 studies involving 2494 patients were included. The comprehensive clinical efficacy of the combination of Banxia Baizhu Tianma Decoction and traditional western medicine (RR = 1.19, 95%CI[1.15,1.23], P ＜ 0.001), left vertebral artery average blood flow velocity (WMD = 5.74，95%CI[4.64, 6.84], P ＜ 0.001), right vertebral artery average blood flow velocity (WMD = 5.58, 95%CI[4.32, 6.84], P ＜ 0.001), mean flow velocity of basilar artery (WMD = 5.04, 95%CI[3.91, 6.18], P ＜ 0.001), whole blood viscosity (low cut) (WMD = -1.30, 95%CI[-2.23, -0.38], P < 0.001), whole blood viscosity (high cut) (WMD = -1.22, 95%CI[-1.48,-0.96], P ＜ 0.001), plasma-viscosity (WMD = -0.26,95%CI[-0.33,-0.18], P < 0.001), fibrinogen(WMD = -0.7,95%CI[-0.99, -0.55], P ＜ 0.001) were better than the control group, and the differences were statistically significant (P ＜ 0.01). Trial sequential analysis further indicated that Banxia Baizhu Tianma Decoction combined with Western medicine had a definite clinical effects in the treatment of VBIV. Conclusion Combining with Banxia Baizhu Tianma Decoction has better comprehensive effect for VBIV. This conclusions still need to be verified by high quality and large sample randomized controlled trials.
2020, Vol. 17 
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