TAM受体及其信号通路在免疫调节中作用的研究进展

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摘要 TAM受体是受体酪氨酸酶的亚家族，包括3个成员Tyro3、Axl和Mertk。其共同配体是生长停滞特异性基因6（Gas6）和蛋白Ｓ（ProS1）。TAM受体和配体广泛表达于哺乳动物免疫、血液、生殖、循环和神经等系统的多种细胞中，具有抑制细胞凋亡、促进细胞增殖和介导细胞黏附、迁移、吞噬凋亡细胞、参与免疫调节等多种生物学功能。TAM受体及其配体在自身免疫性疾病中扮演着重要的角色。

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	解利红1 王宝军2▲

关键词 ： TAM受体, 特异性基因6, 蛋白S, TAM 信号通路, 自身免疫性疾病

Abstract：TAM receptor is a subfamily of receptor tyrosinase, including three members Tyro3, Axl and Mertk. The common ligands of the TAM receptors are growth arrest specific gene 6 (Gas6) and S protein (ProS1). TAM receptors and ligands are widely expressed in mammalian immune, blood, reproductive, circulatory and nervous systems, and have many biological functions, such as inhibiting cell apoptosis, promoting cell proliferation, mediating cell adhesion, migration, phagocytic apoptotic cells, and participating in immune regulation. TAM receptors andits ligands play an important role in autoimmune diseases.

Key words： TAM receptor Specific gene 6 S protein TAM signal pathways Autoimmune diseases

基金资助:国家自然科学基金资助项目（81860210）。

通讯作者: ▲通讯作者

引用本文:

解利红1 王宝军2▲. TAM受体及其信号通路在免疫调节中作用的研究进展[J]. 中国医药导报, 2020, 17(21): 34-37.
XIE Lihong1 WANG Baojun2▲. Research progress of TAM receptors and its signaling pathways in immune regulation. 中国医药导报, 2020, 17(21): 34-37.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I21/34

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