Effect of needle-pricking combined with Compound Se-rich Chinese Angelica Herba Epimedium Mixture on the quality of semen and acrosin activity
YANG Chao1 CUI Yingdong1 LIAO Zhaolin1 SONG Zhangxing1 ZHAO Hua1 XIANG Shengkan2
1.Department of Urology and Andrology, the National Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Province, Enshi 445000, China;
2.The National Hospital of Enshi Tujia and Miao Autonomous Prefecture Affiliated to Hubei Institute for Nationalities, Hubei Province, Enshi 445000, China
Abstract:Objective To investigate the effects of needle-pricking combined with Compound Se-rich Chinese Angelica and Herba Epimedium Mixture on sperm quality and acrosin activity in the treatment of oligospermia and asthenospermia. Methods Fifty cases of patients with oligospermia and asthenospermia admitted to Department of Urology and Andrology, the National Hospital of Enshi Tujia and Miao Autonomous Prefecture from March 2016 to March 2018 were selected. They were divided into control group and observation group by simple random method, with 25 cases in each group. The control group was treated with needle pricking, while the observation group was treated with needle-pricking combined with Compound Se-rich Chinese Angelica Herba Epimedium Mixture. The situation of sperm quality (sperm density, percentage of Grade a sperm, percentage of Grade a+b sperm) and acrosin activity before and after treatment and total effective rate after treatment were compared between the two groups. Results After 3 months of treatment, sperm density, percentage of Grade a sperm, percentage of Grade a+b sperm and acrosin activity of the two groups were significantly higher than those before treatment (P < 0.05), and the growing rate of observation group increased dramaticly than the control group (P < 0.05). The total effective rate of the observation group was higher than that of the control group (P < 0.05). Conclusion Needle-pricking combined with Compound Se-rich Chinese Angelica and Herba Epimedium Mixture can improve semen quality and acrosin activity of patients with oligospermia and asthenospermia effectively.
杨超1 崔应东1 廖兆琳1 宋章兴1 赵华1 向圣坎2. 针挑联合复方富硒当归淫羊藿合剂对精液质量和精子顶体酶活性的影响[J]. 中国医药导报, 2019, 16(6): 54-57.
YANG Chao1 CUI Yingdong1 LIAO Zhaolin1 SONG Zhangxing1 ZHAO Hua1 XIANG Shengkan2. Effect of needle-pricking combined with Compound Se-rich Chinese Angelica Herba Epimedium Mixture on the quality of semen and acrosin activity. 中国医药导报, 2019, 16(6): 54-57.
[1] Dade R,Gupta NP,Kucheria K. Molecular screening for Yq microdeletion in men with idiopathic oligozoospermia and azoospermia [J]. J Biosci,2003,28(2):163-168.
[2] 张志杰,陈小均,贾玉森,等.中医对少弱精子症的临床治疗研究进展[J].中国性科学,2015,24(9):71-74.
[3] 朱彤,吴媛媛,陈素华,等.无精子症及少弱精子症2436例患者的细胞遗传学病因分析[J].现代妇产科进展,2017, 26(6):422-425.
[4] 蒲江波,李雪梅,朱文杰,等.绒促性素联合小剂量雄激素治疗少精子症及弱精子症效果观察[J].山东医药,2016, 56(30):89-91.
[5] 欧卓荣,杨颖辉,徐福松.中医药诊治男性少弱精子症的Meta分析[J].中华中医药学刊,2015,33(9):2268-2273.
[6] 陈栋,钟键,陈恕仁,等.针挑治疗男性不育症的临床观察及对精子质量和激素水平的影响[J].北京中医药大学学报,2012,35(11):773-777.
[7] 张朋飞.针刺结合麒麟丸治疗肾阳虚型少弱精症的临床观察[D].哈尔滨:黑龙江省中医药科学院,2018.
[8] 陈栋.男科学[M].广州:暨南大学出版社,2007:210-217.
[9] World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction [M]. Cambridgeshire:Cambridge University Press,1999:128.
[10] 世界卫生组织.不育夫妇标准检查与诊断手册[M].3版.北京:北京协和医院国际科学技术研究所,2009:18-29.
[11] 梁光林,李永强,陈晓文,等.精子顶体酶活性与精液有关参数的研究[J].上海医药,2018,39(15):53-54,65.
[12] 孙雪,张蛟,桑敏,等.男性不育症病因探讨[J].吉林中医药,2016,36(6):560-564.
[13] 郭丽媛,王鼎,周华,等.不明原因不育男性精子顶体酶活性与精子膜表面抗体检测分析[J].广州医学院学报,2017,45(1):10-12.
[14] 庄锡伟,黎志全,刘冰.精子顶体酶研究概况[J].广西中医药大学学报,2016,19(1):107-109.
[15] Nieschlag S,BehRe HM. Androiogy Male Reproductive Health and Dysfunction [M]. New York:Springer-Verlag,2000.
[16] 郑瑞芹,安会芹,刘晓芹,等.锌硒宝配伍生精丸治疗特发性少弱精子症临床效疗分析[J].生殖与避孕,2007, 27(3):237-239.
[17] Zhao J,Dong X,Hu X,et al. Zinc lewels in seminal plasma and their correlation with male inferility:A systermatic review and meta -analysis [J]. Sci Rep,2016,6:22386.
[18] Moslemi MK,Tavanbaskhsh S. Selenium-vitamin E supplementation in infertile me:effects on semen parameters and pregnancy rate [J]. Int J Gen Med,2011,4:99-104.
[19] Ross C,Morriss A,Khairy M,et al. A systematic review of the effect of oral ntioxidants on male infertility [J]. Reprod Biomed Online,2010,20(6):711-723.
[20] 刘小培,海艺贝,张晓勇,等.补肾填精方联合维生素E、硒酵母片治疗肾精亏虚型特发性弱精子症的临床观察[J].中医药导报,2018,24(5):84-87.
[21] 周灵忠.针挑联合补肾健脾汤治疗男性不育弱精子症疗效及对精液质量和精子顶体酶活性的影响[J].按摩与康复医学,2018,9(7):60-61.
[22] 朱纪伟,丘勇超.生精固本汤联合抗氧化剂治疗少弱精子症临床观察[J].光明中医,2018,33(12):1682-1684.
[23] 余明,戴光忠,杨登银,等.对世界硒都恩施州富硒生态养生旅游开发的思考[J].资源环境与工程,2015,29(2):233-235.
[24] 张宇,张美德,程天周.恩施富硒区十种常见药用植物聚硒能力调查[J].湖北农业科学,2018,57(16):14-15,29.
[25] 唐万贵,谭家珍,张思波,等.超富硒药材恩施堇叶碎米荠的研究[J].西部中医药,2018,31(7):137-139.
[26] 赖海标,曾晔,钟亮,等.当归注射液穴位注射对精索静脉曲张高位结扎术后精液质量变化的临床观察[J].国际医药卫生导报,2006,12(13):91-92.
[27] 高学勇,林珊,韩咪莎.淫羊藿苷对环磷酰胺诱导生精障碍大鼠下丘脑-垂体-睾丸轴的影响[J].解剖学杂志,2018,41(2):147-151.
[28] 葛斌,石燕,王露娟.淫羊藿苷对大鼠精子质量和精核蛋白作用的影响[J].现代医药卫生,2018,34(3):366-368.
[29] 周文,陆杉,周欢群,等.丹参水提液对小鼠睾丸生精功能及精子DNA损伤的影响[J].广东医学,2017,38(8):1159-1163.
[30] 郭蕊蕊.菟丝子中黄酮类成分对人精子细胞活力的影响[D].兰州:兰州大学,2018.
[31] 许一新,叶小珍,马健,等.黄芪多糖对雄性肥胖小鼠精子蛋白酪氨酸磷酸酶1B表达及顶体反应的影响[J].中华实用诊断与治疗杂志,2015,29(11):1056-1058.
[32] 海热尼沙·黑提甫.小茴香提取物对大鼠脂质过氧化作用的研究[J].当代医药论丛,2014,12(6):128-129.
[33] 彭祚全,黄剑锋.世界硒都恩施硒资源研究概述[M].北京:清华大学出版社,2012:8.