Clinical efficacy of Ginkgo bilobate extract combined with deproteinized calf blood extratives for injection in the treatment of acute cerebral infarction
HUANG Heming1 GAO Xia1 ZHANG Rui1 CHEN Shi1 ZOU Liangyu2
1.Department of Geratology, the First Affiliated Hospital of Medical College of Southern University of Science and Technology the Second Clinical Medical College of Ji′nan University Shenzhen People′s Hospital, Guangdong Province, Shenzhen 518020, China;
2.Department of Neurology, the First Affiliated Hospital of Medical College of Southern University of Science and Technology the Second Clinical Medical College of Ji′nan University Shenzhen People′s Hospital, Guangdong Province, Shenzhen 518020, China
Abstract：Objective To investigate the clinical efficacy of Ginkgo bilobate extract combined with deproteinized calf blood extratives for injection in the treatment of acute cerebral infarction. Methods A total of 80 patients with acute cerebral infarction admitted to Shenzhen People′s Hospital from February 2013 to December 2017 were selected. Patients were divided into control group (40 cases) and study group (40 cases) by random number table method, and the control group was treated with deproteinized calf blood extratives for injection, while the study group was treated with Ginkgo bilobate extract on the basis of the control group treatment. The clinical efficacy of the two groups after treatment was compared. Serological indicators were compared between the two groups before and after treatment, including the serum levels of interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), endothelin-1 (ET-1), nitric oxide (NO), and hemorheological index. The incidence of adverse reactions during the treatment of the two groups was recorded and compared. Results The total effective rate of the study group was significantly higher than that of the control group (P ＜ 0.05). After treatment, the levels of IL-6, hs-CRP, TNF-α and ET-1 in the two groups were lower than those before treatment, and those in the study group were lower than those in the control group (P ＜ 0.05); NO was higher than that before treatment, and that in the study group was higher than that in the control group (P ＜ 0.05). After treatment, the plasma viscosity, blood viscosity, hematocrit and erythrocyte aggregation index of the two groups were lower than those before treatment, and those in the study group were lower than those in the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P ＞ 0.05). Conclusion Ginkgo bilobate extract combined with deproteinized calf blood extratives for injection is effective in the treatment of acute cerebral infarction. It can maintain the stability of hemorheological index, improve the serological indicator of the patients, and the therapy does not increase the incidence of adverse reactions. It has certain clinical application value.
2019, Vol. 16 
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