Multicenter survey of Mycoplasma pneumoniae infection and 23S rRNA mutation in children in Taizhou region
YING Xiaoming1 WANG Lizhen2 ZHENG Changhua3 YANG Shanpu4
1.Department of Pediatrics, Taizhou First People′s Hospital Huangyan Hospital Affiliated to Wenzhou Medical University, Zhejiang Province, Taizhou 318020, China; 2.Department of Pediatrics, Taizhou Hospital of Zhejiang Province, Zhejiang Province, Taizhou 317000, China;
3.Department of Pediatrics, the First People′s Hospital of Wenling, Zhejiang Province, Wenling 317500, China;
4.Department of Pediatrics, the People′s Hospital of Yuhuan, Zhejiang Province, Yuhuan 317600, China
Abstract：Objective To know about the infection conditions of Mycoplasma pneumonia (MP) and conditions of drug resistance to macrolides of children with acute respiratory infection in Taizhou region. Methods Through multicenter investigation of pediatric departments in the 4 hospitals of Taizhou First People′s Hospital, Taizhou Hospital of Zhejiang Province, the First People′s Hospital of Wenling and the People′s Hospital of Yuhuan, the respiratory tract samples of 4395 cases of children with acute respiratory infection were collected from January 2016 to December 2017. Real-time PCR was used to detect the positive rates of MP and the mutations of its drug resistance gene (23S rRNA). Then the clinical data was analyzed. Results The results of Real-time PCR showed that among 4395 children with acute respiratory infection, 742 cases were MP positive, the infection rate was 16.88%, among whom, there were 422 cases of mutation of 23S rRNA, the mutation rate was 56.87%. There was statistically significant difference of the positive rates of MP among different seasons (P ＜ 0.05), among which, summer (23.56%) was the highest. There was statistically significant difference in the positive rates of MP among different age groups (P ＜ 0.05), and it increased with age. There was no significant difference in infection rate of MP between children of different sexes (P ＞ 0.05); there was no significant difference in mutation rate of 23S rRNA among children of different seasons and sexes (P ＞ 0.05); and there was statistically significant difference in mutation rate of 23S rRNA among children of different ages (P ＜ 0.05). Conclusion This multicenter combining research shows that MP infection may have correlation with climate and age. MP infection is more common in summer and older children. At the same time, MP has higher drug resistance rates for macrolides.
2019, Vol. 16 
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