Abstract：Objective To study the relationship between the imbalance of Th17/Treg cells and the degree of disease activity and inflammation in patients with ulcerative colitis (UC). Methods Ninety-three patients with UC from January 2017 to May 2018 admitted to Yunnan Geriatric Hospital (“our hospital” for short) were selected and studied. Among the patients, 56 cases in UC active period were as the active period group, 37 cases in remission period were as the remission period group. The active stage group was divided into subgroups according to the modified Mayo scoring: 19 cases in the mild group, 24 cases in the moderate group, and 13 cases in the severe group. Another 40 healthy volunteers undergoing physical examination in the same period were selected as the control group. The levels of Th17/Treg, C-reactive protein (CRP), interleukin (IL)-10, IL-17 were detected and compared. Th17, Treg cells in each group were measured and the relationship between Th17, Treg cells and disease activity and inflammation was analyzed. Results The proportion of Th17 cells and the level of Th17/Treg in the active period group and the remission period group were significantly higher than the control group, and those in the active period group were significantly higher than the remission period group (P ＜ 0.05), and the proportion of Treg cells in the active period group was significantly lower than the control group (P ＜ 0.05). Th17/Treg level in the severe group was significantly higher than the mild group and moderate group, and the proportion of Th17 cells was significantly higher than the mild group (P ＜ 0.05). The proportion of Treg cells in the severe group was significantly lower than the mild group and moderate group (P ＜ 0.05). The CRP and IL-17 in the active period group and the remission period group were significantly higher than the control group, and the CRP and IL-17 in the active period group were significantly higher than the remission period group (P ＜ 0.05). The IL-10 in active period group and remission period group was significantly lower than the control group (P ＜ 0.05). The CRP and IL-17 in the severe group were significantly higher than the mild group (P ＜ 0.05). The CRP in the severe group was significantly higher than the mild group, and the CRP in the severe group was significantly higher than the mild group (P ＜ 0.05). According to Pearson correlation analysis method, the Th17 cells and Th17/Treg were positively correlated with disease activity and IL-17, and was negatively correlated with IL-10 (P ＜ 0.05). The Treg cells was negatively correlated with disease activity, CRP, IL-17 and positively correlated with IL-10 (P ＜ 0.05). Conclusion There is a close relationship between the imbalance of Th17/Treg cells and the degree of disease activity and inflammation in the patients with UC. The balance of Th17/Treg cells in patients with UC should be ensured as much as possible in clinic, which is beneficial to the prevention and control of the disease.
何智超 林楠 尹丕发. Th17/Treg细胞失衡与溃疡性结肠炎患者疾病活动度及炎症程度的关系[J]. 中国医药导报, 2019, 16(5): 130-133.
HE Zhichao LIN Nan YIN Pifa. The relationship between the imbalance of Th17/Treg cells and the degree of disease activity and inflammation in patients with ulcerative colitis. 中国医药导报, 2019, 16(5): 130-133.
2019, Vol. 16 
京公网安备 11010502046598号