MAO Mingqing1，3 FANG Li′na2 JIA Hui3 HE Wei3 XIA Shuyue3
1.Shenyang Medical College, Liaoning Province, Shenyang 110034, China;
2.College of Basic Medical Science, Shenyang Medical College, Liaoning Province, Shenyang 110034, China;
3.Department of Respiratory, the Central Hospital Affiliated to Shenyang Medical College, Liaoning Province, Shenyang 110024, China
Abstract：Doxofylline is a methylxanthine derivative that acts as a new bronchodilator with good pharmacological effects and clinical efficacy in the treatment of chronic obstructive pulmonary disease and asthma. Compared with traditional theophylline, doxofylline has the characteristics of not antagonizing calcium channel receptors, nor affecting calcium influx, and has a weak affinity for adenosine A1 and A2 receptors, so it does not affect heart rate and rhythm, sleep rhythm, central nervous system (CNS) function and gastric secretion, and has good safety and tolerance. This article reviews the research progress of doxofylline in order to provide reference for the majority of medical workers.
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2019, Vol. 16 
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