Research progress on the correlation between high mobility group box chromosomal protein l and rheumatoid arthritis
LIU Wei1* HUANG Jian1* CHEN Caixia2 WANG Dan3
1.Department of Joint Surgery, the Second Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010010, China; 2.Clinical Medical Research Center, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010010, China;
3.Geriatric Medical Center, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010010, China
Abstract：Rheumatoid arthritis is a chronic non-specific inflammatory disease of the joint synovium with joint lesions as the main manifestation, and the course of disease is progressive. High mobility group box chromosomal protein 1 is involved in the evolution and progression of various autoimmune diseases as a potential inflammation-inducing factor. And the abnormal expression of high mobility group box chromosomal protein 1 is closely related to the occurrence and development of rheumatoid arthritis. This article further elaborates and demonstrates that the expression of high mobility group box chromosomal protein 1 in serum of patients with rheumatoid arthritis promotes the up-regulation of inflammatory factor-related receptors, but its correlation with clinical indicators is still unclear. The expression of high mobility group box chromosomal protein 1 in synovial membrane in patients with rheumatoid arthritis promotes synovial inflammatory expression. High mobility group box chromosomal protein 1 promotes the synthesis and release of inflammatory cytokines, pathological proliferation, apoptosis, autophagy and irreversible progression of phenotypic transformation in synovial fibroblasts in rheumatoid arthritis. In theory, it provides a new target for the clinical diagnosis and disease intervention of rheumatoid arthritis.
刘伟1* 黄健1* 陈彩霞2 王丹3. 高迁移率族蛋白1与类风湿性关节炎的相关性研究进展[J]. 中国医药导报, 2019, 16(31): 46-51,55.
LIU Wei1* HUANG Jian1* CHEN Caixia2 WANG Dan3. Research progress on the correlation between high mobility group box chromosomal protein l and rheumatoid arthritis. 中国医药导报, 2019, 16(31): 46-51,55.
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