Retrospective analysis of clinicopathological features of IgA nephropathy with dyslipidemia
HOU Haizhu1 LUO Jing2 GUO Hui1
1.Department of Nephrology, the Second Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030001, China;
2.Department of Rheumatology, the Second Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030001, China
Abstract：Objective To explore the differences in clinicopathological features of IgA nephropathy with different dyslipidemia. Methods The clinicopathological data of 173 patients diagnosed as IgA nephropathy at the Second Hospital of Shanxi Medical University from August 2015 to August 2018 was collected. Patients with dyslipidemia were divided into hypercholesterolemia group, hypertriglyceridemia group, low high-density lipoproteinemia group and mixed hyperlipidemia group, while patients with normal blood lipids were used as a control group. The differences in clinicopathological parameters among five groups were compared, and a multiple stepwise regression model was established to investigate the estimated glomerular filtration rate (eGFR). Results The 24-hour urine protein level in the hypercholesterolemia group was higher than that in the control group, while serum albumin (Alb) was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). The proportion of males, age, body mass index (BMI), serum creatinine (Scr), uric acid (UA), and Oxford classification (T rating) in the hypertriglyceridemia group were higher than those in the control group, while eGFR was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). The proportion of males, BMI, Scr, UA and hemoglobin (Hb) in the low high-density lipoproteinemia group were higher than those in the control group, while the eGFR was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). BMI, 24 h urine protein quantitation and Hb in the mixed hyperlipidemia group were higher than those in the control group, while eGFR and Alb were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). The regression equation showed that gender, Hb and eGFR were positively correlated; age, UA, and Oxford classification were negatively correlated with eGFR. Conclusion The degree of clinical pathological damage in patients with IgA nephropathy with different dyslipidemia types is not completely the same, and hypertriglyceridemia might be a risk factor for renal interstitial fibrosis in IgA nephropathy.
侯海珠1 罗静2 郭珲1. 伴血脂异常IgA肾病临床病理特征的回顾性分析[J]. 中国医药导报, 2019, 16(27): 73-76,80.
HOU Haizhu1 LUO Jing2 GUO Hui1. Retrospective analysis of clinicopathological features of IgA nephropathy with dyslipidemia. 中国医药导报, 2019, 16(27): 73-76,80.
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2019, Vol. 16 
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