Abstract：Objective To study the clinical effect of Guizhi Fuling Capsules combined with desdrogesterone in the treatment of endometrial uneven echo detected by transvaginal ultrasound. Methods From January to October 2018, 60 cases of abnormal uterine bleeding with endometrial uneven echo by ultrasound within 10 days of menstruation were collected in the Department of Gynecology of Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine. According to their actual medication method, they were divided into observation group and control group, 30 cases in each group. The control group was treated with Dydrogesterone only in the second half of menstruation (from 15th to 25th day), while the observation group was treated with Dydrogesterone in the second half cycle (the same as the control group) and Guizhi Fuling Capsules on the 20th day of menstruation for 11 days. The clinical effects and adverse reactions of the two groups were recorded. Results After 3 months of treatment, the thickness of endometrium, rate of slightly higher echo in uterine cavity and the uneven rate of endometrial echo in both groups decreased significantly compared with before treatment, the differences were statistically significant (P < 0.05 or P < 0.01); the thickness of endometrium in observation group was lower than that of the control group, the difference was statistically significant (P < 0.05); There were no statistically significant differences in the rate of slightly higher echo in uterine cavity and the uneven rate of endometrial echo between the two groups (P > 0.05). There was no obvious adverse reactions occurred in the two groups. Conclusion Guizhi Fuling Capsules combined with Dydrogesterone in the treatment of endometrial uneven echo by ultrasound can improve the clinical efficacy and abnormal uterine bleeding, without increasing the incidence of adverse reactions, which is safe and reliable.
[1] Fraser IS，Mansour D，Breymann C，et al. Prevalence of heavy menstrual bleeding and experiences of affected women in a European patient survey [J]. Int J Gynaecol Obstet，2015，128（3）：196-200.
[2] Kazemijaliseh H，Ramezani Tehrani F，Behboudi-Gandevani S，et al. A Population-Based Study of the Prevalence of Abnormal Uterine Bleeding and its Related Factors among Iranian Reproductive-Age Women：An Updated Data [J]. Arch Iran Med，2017，20（9）：558-563.
[3] Deneris A. PALM-COEIN Nomenclature for Abnormal Uterine Bleeding [J]. J Midwifery Womens Health，2016，61（3）：376-379.
[4] Walker MH，Borger J. Menorrhagia [M]. Treasure Island （FL）：StatPearls Publishing，2019.
[5] Clark TJ，Middleton LJ，Cooper NA，et al. A randomised controlled trial of Outpatient versus inpatient Polyp Treatment （OPT） for abnormal uterine bleeding [J]. Health Technol Assess，2015，19（61）：1-194.
[6] Uglietti A，Mazzei C，Deminico N，et al. Endometrial polyps detected at ultrasound and rate of malignancy [J]. Arch Gynecol Obstet，2014，289（4）：839-843.
[7] Clark TJ，Stevenson H. Endometrial Polyps and Abnormal Uterine Bleeding （AUB-P）：What is the relationship，how are they diagnosed and how are they treated? [J]. Best Pract Res Clin Obstet Gynaecol，2017，40：89-104.
[8] Dueholm M，Hjorth IM. Structured imaging technique in the gynecologic office for the diagnosis of abnormal uterine bleeding [J]. Best Pract Res Clin Obstet Gynaecol，2017， 40：23-43.
[9] Munro MG，Critchley HO，Broder MS，et al. FIGO classification system （PALM-COEIN） for causes of abnormal uterine bleeding in nongravid women of reproductive age [J]. Int J Gynaecol Obstet，2011，113（1）：3-13.
[10] 谈勇.中医妇科学[M].北京：中国中医药出版社，2016.
[11] 李灿东.中医诊断学[M].北京：中国中医药出版社，2016.
[12] 张华冬，何秀容，廖湘萍，等.桂枝茯苓丸联合下腹部微波治疗原发性痛经的疗效观察[J].国际医药卫生导报， 2014，20（11）：1500-1502.
[13] 张雅慧.慢性盆腔炎采用桂枝茯苓丸加减治疗临床疗效观察[J].东方食疗与保健，2018（1）：276.
[14] 黄浔芳.桂枝茯苓丸治疗子宫内膜异位症的疗效观察[J].当代医学，2013，19（31）：96-96.
[15] 樊斌.加味桂枝茯苓丸治疗子宫肌瘤临床疗效分析[J].世界最新医学信息文摘：连续型电子期刊，2015，15（79）：178，185.
[16] 周秀娟.桂枝茯苓丸治疗卵巢囊肿临床观察[J].亚太传统医药，2014，10（16）：61-62.
[17] 唐菲，於建鹏，张松.白芍配伍桂枝抗炎的药理学作用及机制[J].湖南中医药大学学报，2012，32（2）：5-6.
[18] Chen DQ，Feng YL，Chen L，et al. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFkappaB/Nrf2 axis [J]. Free Radic Biol Med，2019，134：484-497.
[19] Li Q，Zhang Y，Sun J，et al. Paeonol-mediated apoptosis of hepatocellular carcinoma cells by NF-κB pathway [J]. Oncol Lett，2019，17（2）：1761-1767.
[20] Lyu ZK，Li CL，Jin Y，et al. Paeonol exerts potential activities to inhibit the growth，migration and invasion of human gastric cancer BGC823 cells via downregulating MMP2 and MMP9 [J]. Mol Med Rep，2017，16（5）：7513-7519.
[21] Li H，Cao W，Lu M，et al. Urinary and Serum Metabolomics Analyses Uncover That Total Glucosides of Paeony Protect Liver against Acute Injury Potentially via Reprogramming of Multiple Metabolic Pathways [J]. Evid Based Complement Alternat Med，2017：9038260.
[22] 吴修红，胡妮娜，李宝龙，等.赤芍与白芍脐中穴给药的药理作用比较研究[J].针灸临床杂志，2014，30（5）：54-56.
[23] Vasquez-Villanueva R，Marina ML，Garcia MC. Identification by hydrophilic interaction and reversed-phase liquid chromatography-tandem mass spectrometry of peptides with antioxidant capacity in food residues [J]. J Chromatogr A，2016，1428：185-192.
2019, Vol. 16 
京公网安备 11010502046598号