Biological characteristics study of CRBSI in patients with CVC
DOU Xinman1 MA Peifen1 NAN Ruiling2 ZHOU Linlin3 ZHANG Yabin3 LI Yumin4▲
1.Department of Nursing, the Second Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China;
2.Wards Three of Emergency and Critical Care, the Second Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China;
3.College of Nursing, Lanzhou University, Gansu Province, Lanzhou 730000, China;
4.Key Laboratory of Digestive System Tumors of Gansu Province, the Second Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China
Abstract：Objective To investigate the bacterial biological characteristics of catheter-related bloodstream infection (CRBSI) in patients with central venous catheter (CVC) catheterization. Methods The bacterial biological characteristics of CRBSI in 16 841 patients with CVC catheterization in the Second Hospital of Lanzhou University from January 2012 to December 2015 were retrospectively analyzed. Hospital information system, laboratory information system and SPSS software were used to analyze the pathogenic microorganisms of CRBSI. Results There were 16 507 cases of single pathogen infection, 331 cases of double infection and 3 cases of triple infection. In total, 16 905 strains of pathogenic bacteria, 8709 strains of Gram-positive bacteria (51.4%), 7875 strains of Gram-negative bacteria (46.7%) and 321 strains of fungi (1.9%) were isolated. MRSA and CNS both showed strong resistance to Penicillin and Oxazacillin. Acinetobacter baumannii had a high resistance to antibiotics, Klebsiella pneumoniae had the highest resistance rate to Cefazolin (82.8%). The drug resistance rate of Pseudomonas aeruginosa to antibiotics was > 50%. Escherichia coli was highly resistant to Ampicillin and Cefazolin (> 70%). Conclusion Patients with CVC catheterization are prone to complicated CRBSI due to pathogenic bacteria infection or multiple complications, and may further develop sepsis or septic shock. The pathogens causing CRBSI are mainly Gram-positive bacteria, Gram-negative bacteria and fungi.
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2019, Vol. 16 
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