细胞外囊泡对肿瘤生物学特性的影响研究进展

摘要
图/表
参考文献(23)
相关文章 (4)

全文: PDF (651 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要肿瘤的生长、侵袭和转移依赖于肿瘤细胞与其所处微环境中基质细胞的“交叉对话”，这种“交叉对话”主要涉及这两种细胞的可溶因子的分泌、膜包囊颗粒的释放以及细胞与细胞间的直接接触。这些膜包囊颗粒被称为细胞外囊泡（EVSs），肿瘤细胞比正常细胞可分泌更多的EVSs，这些EVSs通过依赖于内体分选复合物蛋白（ESCRT）和不依赖于ESCRT的途径将蛋白质、DNA、RNA等“内容物”分选入体内。这些“内容物”促进肿瘤细胞与基质细胞之间的信息的转递，从而支持肿瘤血管生成，侵袭转移、耐药及使得肿瘤细胞获得恶性表征。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	贺玲1 张小燕2 杨雅芝3 李剑3▲

关键词 ：细胞外囊泡, 信号分选, 肿瘤微环境, 肿瘤-基质细胞

Abstract：Tumor growth, invasion and metastasis depend on the "cross-talk" between tumor cells and stromal cells in their microenvironment, which mainly involves the secretion of soluble factors of these two kinds of cells, the release of membrane-tomont particles and the direct contact between cells. These vesicles are known as extracellular vesicles (EVSs), and tumor cells secrete more EVSs than normal cells, which separate proteins, DNA, RNA, and other "contents" into the body through both escrt-dependent and escrt-independent pathways. These "contents" facilitate the transmission of information between tumor cells and stromal cells, thus supporting tumor angiogenesis, invasion and metastasis, drug resistance, and malignant characterization of tumor cells.

Key words： Extracellular vesicles Signal sorting Tumor microenvironment Tumor-stroma cell

基金资助:江西省教育厅科学技术研究项目（GJJ161453）。

通讯作者: ▲通讯作者

引用本文:

贺玲1 张小燕2 杨雅芝3 李剑3▲. 细胞外囊泡对肿瘤生物学特性的影响研究进展[J]. 中国医药导报, 2019, 16(19): 62-65.
HE Ling1 ZHANG Xiaoyan2 YANG Yazhi3 LI Jian3▲. Advance in research on the effects of extracellular vesicles on the biological characteristics of tumor. 中国医药导报, 2019, 16(19): 62-65.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I19/62

[1] Henne WM，Buchkovich NJ，Emr SD. The ESCRT pathway [J]. Dev Cell，2011，21（1）：77-91.
[2] Wang Q，Lu Q. Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling [J]. Nat Commun，2017，8（1）：709.
[3] Trajkovic K，Hsu C，Chiantia S，et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes [J]. Science，2008，319（5867）：1244-1247.
[4] van Niel G，Wubbolts R，Broeke T，et al. Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination [J]. Immunity，2006，25（6）：885-894.
[5] Ratajczak J，Miekus K，Kucia M，et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors：EVsidence for horizontal transfer of mRNA and protein delivery [J]. Leukemia，2006，20（5）：847-856.
[6] Valadi H，Ekstrom K，Bossios A，et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells [J]. Nat Cell Biology，2007，9（6）：654-659.
[7] Pegtel DM，Cosmopoulos K，Thorley DA，et al. Functional delivery of viral miRNAs via exosomes [J]. Proc Natl Acad Sci USA，2010，107（14）：6328-6333.
[8] Thomou T，Mori MA，Dreyfuss JM，et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues [J]. Nature，2017，542（7642）：450-455.
[9] Sansone P，Savini C，Kurelac I，et al. Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer [J]. Cell Reports，2017，114（43）：E9066-E9075.
[10] Takahashi A，Okada R，Nagao K，et al. Exosomes maintain cellular homeostasis by excreting harmful DNA from cells [J]. Nat Commun，2017，8：15 287.
[11] Takasugi M，Okada R，Takahashi A，et al. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 [J]. Nat Commun，2017，8：15 729.
[12] Imjeti NS， Menck K，Egea-Jimenez AL，et al. Syntenin mediates SRC function in exosomal cell-to-cell communication [J]. Nat Commun，2017，114（47）：12 495-12 500.
[13] Wei Y， Wang D， Jin F，et al. Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein [J]. Nat Commun，2017，8：140-141.
[14] Li L，Li C，Wang S，et al. Exosomes derived from hypoxic oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a prometastatic phenotype [J]. Cancer Res，2016，76（7）：1770-1780.
[15] Imjeti S，Menck K，Jimenez A，et al. Syntenin mediates SRC function in exosomal cell-to-cell communication [J]. Cancer Res，2017，114（47）：12 495-12 500.
[16] Nabet BY，Qiu Y，Shabason JE，et al. Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer [J]. Cell，2017，170（2）：352-366.
[17] Webber J，Spary L，Sanders A，et al. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes [J]. Oncogene，2015，34（3）：290-302.
[18] Baglio S，Lagerweij T，Pérez-Lanzón M，et al. Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression Clinical [J]. Cancer Res，2017，23（14）：3721-3733.
[19] Feng Q，Zhang C，Lum D，et al. A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis [J]. Nat Commun，2017，8：14 450.
[20] Godlewski J，Ferrer-Luna R，Rooj AK，et al. Mine MicroRNA signatures and molecular subtypes of glioblastoma：the role of extracellular transfer Stem [J]. Stem Cell Reports，2017，8（6）：1497-1505.
[21] Zhang L，Zhang S，Yao J，et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth [J]. Nature，2015，527（7576）：100-104.
[22] Godlewski J，Ferrer-Luna R，Rooj AK，et al. Mine MicroRNA signatures and molecular subtypes of glioblastoma：the role of extracellular transfer [J]. Stem Cell Reports，2017，8（6）：1497-1505.
[23] Melo S，Sugimoto H，O′Connell JT，et al. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis [J]. Cancer Cell，2014，26（5）：707-721.