血浆N端B型脑钠肽前体及左房容积与房颤导管射频消融术后复发的相关性分析

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摘要目的研究探讨血浆N端B型脑钠肽前体（NT-proBNP）及左房容积（LAV）与房颤患者房颤导管射频消融术后复发的相关性。方法选择2017年5月~2018年1月在中国科学技术大学附属第一医院进行治疗的阵发性心房颤动患者106例为研究对象，所有患者均进行房颤导管射频消融术，采用化学发光法检测术前血浆NT-proBNP水平，采用经食道心脏超声测量患者的LAV。术后随访3个月，根据是否复发将患者分为复发组和非复发组，采用Logistic多因素回归分析房颤导管射频消融术后复发的危险因素。结果术后随访观察显示，术后有16例复发患者，复发率为14.68%。复发组患者的血浆NT-proBNP及LAV均高于非复发组，差异有统计学意义（P < 0.05）。Logistic多因素回归分析显示，血浆NT-proBNP及LAV为阵发性房颤导管射频消融术后复发的独立危险因素（P < 0.05）。结论阵发性房颤导管射频消融术后复发患者的术前血浆NT-proBNP及LAV是术后复发的独立危险因素，术前检测血浆NT-proBNP及LAV有助于预测患者术后的复发情况。

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	郭飞徐健苏浩朱红军陈康玉朱静

关键词 ：心房颤动, 房颤导管射频消融术, 术后复发, 危险因素

Abstract：Objective To investigate the correlation of N-terminal pro-brain natriurctic peptide (NT-proBNP) and left atrial volume (LAV) with the recurrence after atrial fibrillation catheter radiofrequency ablation in patients with atrial fibrillation. Methods One hundred and six patients with paroxysmal atrial fibrillation treated in First Affiliated Hospital of University of Science and Technology of China from May 2017 to January 2018 were selected as the research subjects, all patients were performed radiofrequency ablation of atrial fibrillation catheter. The plasma NT-proBNP level before operation was detected by chemiluminescent immunoassay, LAV of the patients was measured by transesophageal echocardiography. Three months was followed-up after operation, according to whether recurrence occurred, the patients were divided into recurrence group and non-recurrence group. Logistic multivariate regression analysis was used to analyze the risk factors for recurrence after radiofrequency catheter ablation of atrial fibrillation. Results Follow-up observation showed that 16 cases recurred after operation, and the recurrence rate was 14.68%. The plasma NT-proBNP and LAV of the recurrence group were higher than those of the non-recurrence group, the differences were statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that plasma NT-proBNP and LAV were independent risk factors for recurrence after radiofrequency catheter ablation of paroxysmal atrial fibrillation (P < 0.05). Conclusion The levels of plasma NT-proBNP and LAV before operation in patients with recurrent atrial fibrillation after radiofrequency catheter ablation are independent risk factors for recurrence after operation, detection of plasma NT-proBNP and LAV before operation can help predict the recurrence of patients after operation.

Key words： Atrial fibrillation Radiofrequency catheter ablation of atrial fibrillation Postoperative recurrence Risk factor

基金资助:安徽省中央引导地方科技发展专项项目（20170 70802D145）。

通讯作者: 徐健（1966.7-），男，博士，主任医师，主要从事心血管内科的研究。

作者简介: 郭飞（1984.8-），男，硕士，主要从事心血管内科的研究。

引用本文:

郭飞徐健苏浩朱红军陈康玉朱静. 血浆N端B型脑钠肽前体及左房容积与房颤导管射频消融术后复发的相关性分析[J]. 中国医药导报, 2018, 15(32): 63-66.
GUO Fei XU Jian SU Hao ZHU Hongjun CHEN Kangyu ZHU Jing. Correlation analysis of N-terminal pro-brain natriurctic peptide and left atrial volume with recurrence after radiofrequency catheter ablation of atrial fibrillation. 中国医药导报, 2018, 15(32): 63-66.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I32/63

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