Abstract：Objective To analyze the effect of Huoxue Ointment combined with herbal fumigation in the treatment of knee osteoarthritis (KOA) and its influence on interleukin-1 beta (IL-1β) and matrix metalloproteinase (MMP-9). Methods Ninety-two patients with KOA admitted to the People′s Hospital of Liuzhou City of Guangxi Zhuang Autonomous Region from September 2015 to August 2017 were selected and randomly divided into the control group and the observation group by envelope method, with 46 cases in each group. The control group was treated with self-made Huoxue Ointment applicator therapy, and the observation group was treated with Huoxue Ointment and Chinese herbal fumigation. After continuous treatment for 2 weeks, the differences of curative effect, levels of IL-1β and MMP-9, visual analogue scale (VAS) score, hospital specialsurgery (HSS) knee score, short form 36 questionnaire (SF-36) score and adverse reactions between the two groups were compared. Results After treatment, the total effective rate of observation group (97.83%) was higher than that of the control group (84.78%), there was a statistically significant difference between the two groups (P ＜ 0.05). After treatment, the levels of serum IL-1 and MMP-9 of the two groups were significantly lower than those before treatment, and the levels of IL-1 and MMP-9 in the observation group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the VAS scores of the two groups were all lower than those before treatment, while the HSS scores and SF-36 scores of the two groups were all higher than those before treatment, the differences were statistically significant (P ＜ 0.05), and the VAS score of observation group was lower than that of control group, the HSS score and SF-36 score were higher than those of control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during the treatment period (P ＞ 0.05). Conclusion Combined application of Huoxue Ointment and herbal fumigation in the treatment of knee osteoarthritis has satisfactory curative effect, which can effectively decrease the levels of serum inflammatory factors, reduce the pain, improve the knee joint activities and quality of life.
周伟 郑红波 冯穗 刘强 李永文. 活血膏联合中药熏药治疗膝关节骨性关节炎的效果及对IL-1β、MMP-9的影响[J]. 中国医药导报, 2018, 15(27): 117-121.
ZHOU Wei ZHENG Hongbo FENG Sui LIU Qiang LI Yongwen. Effect of Huoxue Ointment combined with herbal fumigation in the treatment of knee osteoarthritis and its influence on IL-1β and MMP-9. 中国医药导报, 2018, 15(27): 117-121.
2018, Vol. 15 
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