高尿酸血症史对糖尿病人群归因危险度的分析

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摘要目的探讨高尿酸血症对糖尿病发病的影响，为预防糖尿病提供科学依据。方法本研究采用队列研究的方法，选择参加2009年7月基线调查并且在2012年12月被随访到的有完整尿酸及糖尿病资料的35～74岁青岛市常驻居民为研究对象，共2177人纳入本次研究。利用非条件Logistic回归计算优势比。用Bruzzi等定义的公式估计人群归因危险度。结果同时控制混杂因素后，高尿酸血症史的OR值为1.497，多因素人群归因危险度为6.71%。结论高尿酸血症史是糖尿病的独立危险因素，青岛市糖尿病的发生部分归因于高尿酸血症史。

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	薛白高汝钦刘丽段海平刘艳

关键词 ：队列研究, 糖尿病, 高尿酸血症, 人群归因危险度

Abstract：Objective To investigate the effect of hyperuricemia on diabetes attack, and provide scientific basis for the work of prevention. Methods Cohort study was conducted in this study. Subjects were selected to participate in the baseline survey in July 2009. A three-year follow-up was conducted for those who met the conditions. The follow-up ended in December 2012. Eventually 2177 people aged 35 to 74 that had lived in Qingdao for years were included in the study. Non-conditional Logistic regression analysis was used to calculate the advantage ratio. The population attributable risk was estimated by using the formula defined by Bruzzi. Results After controlling for confounding factors, the OR value of hyperuricemia was 1.497. The attributional risk of multifactorial population was 6.71%. Conclusion Hyperuricemia is a risk factor for diabetes, and diabetes is caused in part by a history of hyperuricemia in Qingdao.

Key words： Cohort study Diabetes Hyperuricemia Population attributable risk

基金资助:世界糖尿病基金青岛糖尿病预防项目（WDF05-108、WDF07-308）；
青岛市优秀青年人才项目（青卫科教字2017-9）

通讯作者: 高汝钦（1963-），男，硕士，主任医师；研究方向：公共卫生、慢病防控。

作者简介: 薛白（1982-），女，博士；研究方向：慢性病防治。

引用本文:

薛白高汝钦刘丽段海平刘艳. 高尿酸血症史对糖尿病人群归因危险度的分析[J]. 中国医药导报, 2018, 15(24): 42-44,54.
XUE Bai GAO Ruqin LIU Li DUAN Haiping LIU Yan. Analysis of the population attributable risk of hyperuricemia on people with diabetes. 中国医药导报, 2018, 15(24): 42-44,54.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I24/42

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