SERPINE2基因rs3795987位点基因多态性与新疆汉族、维吾尔族慢性阻塞性肺疾病的相关性研究

摘要
图/表
参考文献(20)
相关文章 (14)

全文: PDF (792 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的研究新疆维吾尔自治区汉族和维吾尔族人群的丝氨酸蛋白酶抑制剂-2(SERPINE2)rs3795987位点的基因多态性与慢性阻塞性肺疾病（COPD）之间的相关性。方法本研究采用病例对照研究，选取2015年1~12月新疆医科大学第五附属医院呼吸科收治的汉族、维吾尔族COPD患者各88例作为病例组，同期汉族、维吾尔族体检健康者各100例为对照组。利用聚合酶链式反应对入选样本人群SERPINE2基因rs3795987位点进行基因型测序，并对结果进行相关统计学分析。结果 ①新疆汉族与维吾尔族COPD患者的rs3795987位点基因型分布差异有统计学意义（P < 0.05）。②新疆汉族与维吾尔族rs3795987位点不同基因型与COPD易感性之间差异无统计学意义（P > 0.05）。结论新疆地区汉族和维吾尔族人群的丝氨酸蛋白酶抑制剂-2基因rs3795987位点基因多态性与COPD的发生无明显相关性。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	刘北林张俣王利平王筠赵静王海旭

关键词 ： SERPINE2, 慢性阻塞性肺疾病, 基因多态性, 病例对照研究

Abstract：Objective To investigate the correlation between the gene polymorphism of serine protease inhibitor -2 (SERPINE2) rs3795987 site and chronic obstructive pulmonary disease (COPD) in Han and Uighur nationality in Xinjiang Uygur Autonomous Region. Methods Case-control studies were used in this study. From January to December in 2015, 88 Han and Uighur nationality COPD patients which were treated in the Department of Respiratory Diseases ofthe Fifth Affiliated Hospital of Xinjiang Medical University were separately selected as the COPD group. Meanwhile, 100 Han and Uighur nationality health people were separately selected as the control group. Genotype sequencing of SERPINE2 gene rs3795987 was performed by polymerase chain reaction, and results were analyzed statistically. Results ①There were statistically significant differences in the distribution of rs3795987 site in the patients with COPD in the Han and Uighur nationality in Xinjiang region (P < 0.05). ②There was no statistically significant difference between different genotypes of rs3795987 sites and COPD susceptibility between the Han and Uighur nationality in Xinjiang region(P > 0.05). Conclusion The gene polymorphism of SERPINE2 rs3795987 site and the occurrence of COPD in Han and Uighur nationality in Xinjiang region have no significant correlation.

Key words： SERPINE2 Chronic obstructive pulmonary disease Gene polymorphism Case-control study

基金资助:新疆维吾尔自治区自然科学基金资助项目（2015 211C170）。

引用本文:

刘北林张俣王利平王筠赵静王海旭. SERPINE2基因rs3795987位点基因多态性与新疆汉族、维吾尔族慢性阻塞性肺疾病的相关性研究[J]. 中国医药导报, 2018, 15(2): 23-26.
LIU Beilin ZHANG Yu WANG Liping WANG Jun ZHAO Jing WANG Haixu. Association of genetic polymorphisms of rs3795987 locus allele in SERPINE2 gene with susceptibility to chronic obstructive pulmonary disease between the Han and the Uygur nationality in xinjiang. 中国医药导报, 2018, 15(2): 23-26.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I2/23

[1] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南[J].中华内科杂志，2002，25（9）：453-460.
[2] 黄克武，王辰.慢性阻塞性肺疾病队列研究的概况与思考[J].中华结核和呼吸杂志，2016，39（11）：910-912.
[3] Laurell CB，Eriksson S. The electrophoretic α1-globulin pattern of serum in α1-antitrypsin deficiency [J]. Scand J Clin Lab Invest，1963，15（2）：132-140.
[4] Demeo DL，Mariani TJ，Lange C，et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease [J]. Am J Hum Genet，2006，78（2）：253-264.
[5] Zhu G，Warren L，Aponte J，et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations [J]. Am J Respir Crit Care Med，2007， 176（2）：167-173.
[6] Castaldi PJ，Hersh CP，Reilly JJ，et al. Genetic associations with hypoxemia and pulmonary arterial pressure in COPD [J]. Chest，2009，135（3）：737-744.
[7] Hirano K，Sakamoto T，Uchida Y，et al. Tissue inhibitor of metalloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease [J]. Eur Respir J，2001，18（5）：748-752.
[8] Silverman EK，Palmer LJ，Mosley JD，et al. Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease [J]. Am J Hum Genet，2002，70（5）：1229-1239.
[9] Hersh CP，DeMeo DL，Silverman EK. National emphysema treatment trial state of the art： genetics of emphysema [J]. Proc Am Thorac Soc，2008，5（4）：486-493.
[10] Shapiro SD，Goldstein NM，Houghton AMG，et al. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice [J]. Am J Pathol，2003，163（6）：2329-2335.
[11] Arja C，Ravuri RR，Pulamaghatta VN，et al. Genetic determinants of chronic obstructive pulmonary disease in South Indian male smokers [J]. PLoS One，2014，9（2）：e89 957.
[12] 陈岩，李玉. SERPINE2基因多态性与慢性阻塞性肺疾病的相关性[J].山东大学学报：医学版，2009，47（7）：111-114.
[13] 凌敏，荣艳，胡翠芬，等.新疆阿克苏农村地区慢性阻塞性肺疾病现况调查[J].中华结核和呼吸杂志，2009，32（9）：712-713.
[14] 凌敏，荣艳，苟安栓，等.新疆农村地区慢性阻塞性肺疾病的危险因素调查[J].中华结核和呼吸杂志，2011，34（9）：666-668.
[15] 加孜那，托哈依，胡晓婷，等.新疆和田农村地区60岁以上维吾尔族人群慢性阻塞性肺疾病的流行病学调查[J].新疆医科大学学报，2010，33（9）：1017-1020.
[16] 王爱华.SERPINE2基因多态性与慢性阻塞性肺疾病的相关性研究[D].济南：山东大学，2012.
[17] 李黎，米热班·热夏提，王怀振，等. SERPINE2 基因多态性与喀什地区维吾尔族COPD的易感性关系[J].新疆医学，2017，47（1）：15-19.
[18] Foreman MG，DeMeo DL，Hersh CP，et al. Polymorphic variation in surfactant protein B is associated with COPD exacerbations [J]. Eur Respir J，2008，32（4）：938-944.
[19] 钟丽.中国云南汉族人群中SERPINE2和GSTP1基因多态与慢性阻塞性肺疾病的相关性研究[D].昆明：云南大学，2009.
[20] Hogg JC，Chu F，Utokaparch S，et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease [J]. N Engl J Med，2004，350（26）：2645-2653.