The application of Dexmedetomidine combined with Sulfentanyl for postoperative analgesia in children's inguinal area
ZHANG Jie1 LI Jianling2 CUI Yan3
1.Department of Anesthesiology, Chengde Hospital of Traditional Chinese Medicine, Hebei Province, Chengde 067000, China;
2.Department of Anesthesiology, Affiliated Hospital of Chengde Medical University, Hebei Province, Chengde 067000, China;
3.Department of Anesthesiology, Chinese People's Liberation Army No. 266 Hospital, Hebei Province, Chengde 067000, China
Abstract：Objective To explore the value of Dexmedetomidine combined with Sulfentanyl for postoperative analgesia in children's inguinal area. Methods From June 2016 to June 2017, 100 cases of inguinal area operation and general anesthesia for children were studied in Chengde Hospital of Traditional Chinese Medicine and Affiliated Hospital of Chengde Medical University. According to the random number table method, they were randomly divided into observation group (n = 50, using Dexmedetomidine combined with Sulfentanyl for postoperative analgesia) and control group (n = 50, conventional analgesics for postoperative analgesia). HR, MAP, Ramsay score, Wong-Baker facial expression scale and adverse reactions were compared at different times after operation (i.e. T1: immediately after operation; T2: postoperative 2 h; T3: postoperative 4 h; T4: postoperative 8 h) between two groups. Results At T2, HR and MAP of children in the two groups were lower than T1, the differences were statistically significant (P < 0.05), while in T1, T2, T3 and T4 time, there was no significant difference in HR and MAP between the two groups and the differences were not statistically significant (P > 0.05). The Ramsay scores at T2, T3 and T4 in two groups were all higher than those at T1, the scores at T2, T3 and T4 in the observation group were higher than those in the control group(P < 0.05). At T2, Wong-Baker facial expression scale scores of two groups were higher than those at T1, Wong-Baker facial expression scale scores of the observation group at T2, T3, T4 were lower than those of the control group, and the differences were all statistically significant (P < 0.05). The incidence of adverse reactions in the observation group was 14.00%, and the incidence of adverse reactions in the control group was 10.00%. There was no statistical significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Dexmedetomidine combined with Sulfentanyl has good analgesic effect in children after inguinal surgery. It has little influence on hemodynamics and safety, and it is worthy of clinical application.
张洁1 李建玲2 崔艳3. 右美托咪定复合舒芬太尼在小儿腹股沟区手术术后镇痛中的应用[J]. 中国医药导报, 2018, 15(16): 80-84.
ZHANG Jie1 LI Jianling2 CUI Yan3. The application of Dexmedetomidine combined with Sulfentanyl for postoperative analgesia in children's inguinal area. 中国医药导报, 2018, 15(16): 80-84.
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2018, Vol. 15 
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