Serum hypersensitivity cTnI level and its correlation with kidney related indicators in patients of chronic kidney disease from 3 to 5 stage
WANG Shanzhi1 ZHU Yongjun1 YE Feng2▲ LI Guoquan1 WEI Chuanwa1 HAN Feng2 LIANG Haiqin1 ZHONG Liangbao1
1.Department of Nephrology, the First Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou 570100, China;
2.Clinical Laboratory, the First Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou 570100, China
Abstract：Objective To analyze the level of serum hypersensitive cardiac troponin I (cTnI) in patients of chronic kidney disease (CKD) from 3 to 5 stage without renal replacement therapy. Methods A total of 180 patients of CKD from 3 to 5 stage without renal replacement therapy, severe arrhythmia, acute myocardial infarction and sepsis were selected in the First Affiliated Hospital of Hainan Medical University from January 2016 to November 2017. Then their serum hypersensitivity cTnI were collected, and the correlation between the level of serum hypersensitivity cTnI and glomerular filtration rate (GFR), age, serum creatinine (Scr), blood urea nitrogen (BUN), blood Cystatin-C (CYS-C) and blood albumin (ALB) were analyzed. Results The rank sum test of multiple independent samples showed that the level of serum hypersensitivity cTnI in patients of CKD from 3 to 5 stage without renal replacement therapy was different, and the difference was statistically significant (P ＜ 0.05). Pearson bivariate correlation displayed hypersensitivity cTnI was linearly correlated with CKD staging, GFR and CYS-C (P ＜ 0.05), and was not linearly correlated with Scr, BUN, ALB and age (P ＞ 0.05). The stepwise multiple linear regression analysis showed that the hypersensitive cTnI regression equation was Y = -0.043+0.023X (Y：cTnI，X：CKD3～5). Conclusion The reference value of cTnI in the patients of CKD from 3 to 5 stage can be corrected according to the hypersensitive cTnI regression equation, and then it can be used as a reference for clinical decision of CKD.
王善志1 朱永俊1 叶凤1▲ 李国铨1 韦传娃1 韩锋2 梁海琴1 钟良宝1. 慢性肾脏病3～5期患者的血清超敏cTnI水平及其与肾脏相关指标的关系[J]. 中国医药导报, 2018, 15(15): 69-71.
WANG Shanzhi1 ZHU Yongjun1 YE Feng2▲ LI Guoquan1 WEI Chuanwa1 HAN Feng2 LIANG Haiqin1 ZHONG Liangbao1. Serum hypersensitivity cTnI level and its correlation with kidney related indicators in patients of chronic kidney disease from 3 to 5 stage. 中国医药导报, 2018, 15(15): 69-71.
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2018, Vol. 15 
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