无症状性脑梗死的临床研究现状
吴向菊 张春梅▲
哈尔滨医科大学附属第一医院超声科,黑龙江哈尔滨 150000
Clinical research situation of asymptomatic cerebral infarction
WU Xiangju ZHANG Chunmei▲
Department of Ultrasound, the First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150000, China
摘要 无症状性脑梗死(ACI)是脑血管病的一种,其发病与年龄、高血压、颈动脉粥样硬化等多种因素相关。由于ACI并不表现出典型的症状和体征,常被医患双方忽视,大部分在体检时才被发现,此时患者脑实质已受损,甚至发生不可逆的病理改变,尽早检出并及时干预和治疗显得极为重要。如不及时控制ACI的危险因素,可增加症状性脑梗死、神经认知功能障碍和精神疾病的风险。目前,ACI多由磁共振成像(MRI)检出,高分辨率MRI可提高ACI的检出率,并降低其误诊率。
关键词 :
无症状性脑梗死 ,
磁共振成像 ,
临床诊断 ,
转归
Abstract :Asymptomatic cerebral infarction (ACI) is a kind of cerebrovascular disease, which is associated with age, hypertension, carotid atherosclerosis and so on. Because of the ACI does not show typical symptoms and signs, both doctors and patients often ignore it, most of them are found by physical examination, at this time the patient's brain parenchyma has been damaged, and even irreversible pathological changes have happened. Early detection, intervention and treatment timely is extremely important. If not timely control the risk factors of ACI, it can increase the risk of cerebral infarction, neurocognitive dysfunction and mental illness. At present, ACI is detected mostly by MRI, high resolution MRI can improve the detection rate of ACI and reduce the misdiagnosis rate.
Key words :
Asymptomatic cerebral infarction
Magnetic resonance imaging
Clinical diagnosis
Outcome
通讯作者:
▲通讯作者
作者简介 : 吴向菊(1989-),女,哈尔滨医科大学附属第一医院2014级超声专业在读硕士研究生;研究方向:血管超声。
[1] Fanning JP,Wong AA,Fraser JF. The epidemiology of silent brain infarction:a systematic review of population-based cohorts [J]. BMC Medicine,2014,12(1):119.
[2] Vermeer SE,Koudstaal PJ,Oudkerk M,et al. Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study [J]. Stroke,2002,33(1):21-25.
[3] Astarci P,Glineur D,Kefer J,et al. Magnetic resonance imaging evaluation of cerebral embolization during percutaneous aortic valve implantation:comparison of transfemoral and trans-apical approaches using edwards sapiens valve [J]. Eur J Cardio Thorac Surg,2011,40(2):475-479.
[4] Fisher MC. Lacunar infarcts-a review [J]. Cerebrovasc Dis,1991,1(6):311-320.
[5] Poels MM,Ikram MA,van der Lugt A,et al. Cerebral microbleeds are associated with worse cognitive function:the Rotterdam Scan Study [J]. Neurology,2012,78(5):326-333.
[6] 杨涛,张岚,汪华,等.无症状性脑梗死患者灰质体积与认知功能研究[J].中国神经精神疾病杂志,2014,40(2):91-96.
[7] Corea F,Tambasco N,Luccioli R,et al. Brain CT-scan in acute stroke patients:silent infarcts and relation to outcome [J]. Clin Exp Hypertens,2002,24(7/8):669-676.
[8] Allen LM,Hasso AN,Handwerker J,et al. Sequence-specific MR Imaging Findings That Are Useful in Dating Ischemic Stroke [J]. Radiographics,2012,32(5):1285-1297.
[9] Moreau F,Patel S,Lauzon ML,et al. Cavitation after acute symptomatic lacunar stroke depends on time,location,and MRI sequence [J]. Stroke,2012,43(7):1837.
[10] Zhu YC,Dufouil C,Mazoyer B,et al. Frequency and location of dilated Virchow-Robin spaces in elderly people:a population-based 3D MR imaging study [J]. Ajnr Am J Neuroradiol,2011,32(4):709-713.
[11] Fanning JP,Wesley AJ,Wong AA,et al. Emerging Spectra of Silent Brain Infarction [J]. Stroke,2014,45(11):3461-3471.
[12] Zhu YC,Dufouil C,Tzourio C,et al. Silent brain infarcts:a review of MRI diagnostic criteria [J]. Stroke,2011,42(4):1140-1145.
[13] 张维文,王晓莉,崔永健,等.无症状脑梗死的临床特征及危险因素分析[J].解放军医药杂志,2016,28(8):81-84.
[14] 孙沄,李洪军,张晨.无症状性脑梗死的危险因素[J].齐鲁医学杂志,2006,21(1):85-89.
[15] Brisset M,Boutouyrie P,Pico F,et al. Large-vessel correlates of cerebral small-vessel disease [J]. Neurology,2013,80(7):662-669.
[16] Baradaran H,Gialdini G,Mtui E. Silent Brain Infarction in Patients With Asymptomatic Carotid Artery Atherosclerotic Disease [J]. J Vasc Surg,2016,64(2):534-535.
[17] 李晓红,粱永耀,赵武民,等.无症状脑梗死干预治疗与急性缺血性脑卒中发生的相关性研究[J].疑难病杂志,2008,7(8):457-459.
[18] 宋雪艳.无症状性脑梗死的临床特征分析[J].中国药物经济学,2016,11(7):108-109.
[19] Olmez I,Ozyurt H. Reactive oxygen species and ischemic cerebrovascular disease [J]. Neurochem Int,2012,60(2):208-212.
[20] Gupta A,Giambrone AE,Gialdini G,et al. Silent Brain Infarction and Risk of Future Stroke:A Systematic Review and Meta-Analysis [J]. Stroke,2016,47(3):719-725.
[21] Koga H,Takashima Y,Murakawa R,et al. Cognitive consequences of multiple lacunes and leukoaraiosisas vascular cognitive e impairment in elderly individuals Community dwelling elderly individual [J]. J Stroke Cerebrovasc Dis,2013,18(1):3237.
[22] Choi P,Ren M,Phan TG,et al. Silent infarcts and cerebral microbleeds modify the associations of whitematter lesions with gait and postural stability:population-based study [J]. Stroke,2012,43(6):1505-1510.
[23] 丛文东,冯丽娜,魏瑞鹏.无症状性腔隙性脑梗死患者认知功能障碍特点及影响因素[J].江西医药,2013,48(3):220-221.
[24] Thong JY,Hilal S,Wang Y,et al. Association of silent lacunarinfarct with brain and cognitive atrophy impairment [J]. J Neurol Neurosurg Psychiatry,2013,84(11):1219-1225.
[25] 高春岭,谭华.无症状性脑梗死认知功能障碍研究进展[J].医学理论与实践,2014,27(9):1142-1143.
[26] Blum S,luchsinger JA,manly JJ,et al. Memory after sile-ntstroke:hippocampus and infarcts both matter [J]. Neurology,2012,78(1):38-46.
[27] Avdibegovic E,Becirovic E,Salimbasic Z,et al. Cerebral cortical atrophy and silent brain infarcts in psychiatric patients [J]. Psychiatr Danub,2007,19(1/2):49-55.
[28] Fujikawa T,Yamawaki S,Touhouda Y. Silent cerebral infarctions in patients with late-onset mania [J]. Stroke,1995,26(6):946-949.
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