Abstract：Pregnancy is an example of the natural allogeneic transplantation. The success of pregnancy depends mostly on a successful immune-endocrine cross-modulation at the maternal–fetal interface. Hormones have important effect on early pregnancy including progesterone, estradiol and human chorionic gonadotrop in play essential roles in the immune crosstalk at the maternal-fetal interface. This review focuses on the immunomodulatory effect of these hormones during early pregnancy on the establishment of maternal-fetus immune tolerance, invasion of trophoblastic cells and formation of placenta. The present review will provide important insights into novel therapeutic strategies of the recurrent spontaneous miscarriage, pre-eclampsia and intrauterine growth restriction.
蒋国静 沈明洁 曾薇薇 齐聪. 母胎界面的免疫-内分泌调控对早期妊娠影响的研究进展[J]. 中国医药导报, 2017, 14(21): 34-37,56.
JIANG Guojing SHEN Mingjie ZENG Weiwei QI Cong. The progress of the effect of immune-endocrine modulation at the maternal-fetal interface on early pregnancy. 中国医药导报, 2017, 14(21): 34-37,56.
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