Abstract：Objective To explore the effect of blue light irradiation combined with abdominal circular massage on neonatal jaundice. Methods Clinical data of 150 patients with neonatal jaundice in the First People's Hospital of Nantong City, Jiangsu Province from June 2015 to December 2016 were retrospectively analyzed. They were divided into two group by different treatment methods, control group (phenobarbital treatment) of 70 cases and observation group (phenobarbital, blue light irradiation combine with abdominal circular massage treatment) of 80 cases. The meconiun turning yellow time, daily defecation number, eliminating jaundice time, bilirubin, clinical effects of two groups were detected. Results The meconiun turning yellow time, eliminating jaundice time in observation group were shorter than those in control group, daily defecation number in observation group was more than that in control group, with statistical differences (P < 0.05). There was no significant difference in the levels of bilirubin before treatment between two groups (P > 0.05). The bilirubin levels of observation group after treatment of 1, 3, 7 d were lower than those of control group, with statistical differences (P < 0.05). With the continuous prolongation of treatment time, the levels of bilirubin in two groups of neonatal jaundice were gradually decreased, the difference was statistically significant (P < 0.05). Total effective rate of clinical treatment of neonatal jaundice in observation group was higher than that in control group, with statistical difference (P < 0.05). Conclusion Clinical symptom of blue light combined with abdominal circular massage in the treatment of neonatal jaundice is improved significantly, bilirubin decreased significantly, the effect is good, it is worthy of clinical promotion and application.
朱媛媛 刘颖▲. 蓝光照射结合腹部环形按摩对新生儿黄疸胆红素和黄疸消退情况的影响[J]. 中国医药导报, 2017, 14(21): 133-136.
ZHU Yuanyuan LIU Ying▲. Influence of blue light irradiation combined with abdominal circular massage on bilirubin and jaundice regression in neonatal jaundice. 中国医药导报, 2017, 14(21): 133-136.
[1] 刘静，张鸾，王二艳.茵栀黄联合蓝光照射治疗新生儿黄疸的疗效及对患儿生长发育的影响[J].医学综述，2016， 22（20）：4114-4116.
[2] Amin SB，Lamola AA. Newborn jaundice technologies：unbound bilirubin and bilirubin bounding capacity in neonatal [J]. Semin Perinatol，2011，35（3）：134-140.
[3] 林方，孙洁.单纯蓝光治疗与复合中药联合治疗新生儿黄疸疗效比较[J].医学综述，2016，22（12）：2474-2476.
[4] Panahi R，Jafari Z，Sheibanizade A，et al. The relationship between the behavioral hearing thresholds and maximum bilirubin levels at birth in children with a history of neonatal hyperbilirubinemia [J]. Iran J Otorhinolaryngol，2013，25（72）：127-134.
[5] 王艳，王翠霞，董玉霞，等.早期排便干预对新生儿黄疸指数的影响分析[J].现代中西医结合杂志，2015，24（29）：3222-3223.
[6] Cuperus FJ，Schreuder AB，van Imhoff DE，et al. Beyond plasma bilirubin：the effects of phototherapy and albumin on brain bilirubin levels in Gunn rats [J]. J Hepatol，2013， 58（1）：134-140.
[7] 王艳，董玉霞，邸红芹，等.脐血胆红素水平及排便干预对新生儿病理性黄疸的影响[J].解放军医药杂志，2015， 27（10）：64-65，68.
[8] Huang L，Bao Y，Xu Z，et al. Neonatal bilirubin levels and childhood asthma in the US collaborative perinatal project，1959-1965 [J]. Am J Epidemiol，2013，178（12）：1691-1697.
[9] 张定芬.间隙和持续蓝光照射治疗新生儿黄疸的临床效果评价[J].黑龙江医药，2016，29（6）：1202-1203.
[10] Cardoso FL，Kittel A，Veszelka S，et al. Exposure to lipo-polysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells [J]. PLoS One，2012，7（5）：e35919-e35928.
[11] 陈旭升.茵栀黄颗粒联合蓝光照射治疗新生儿黄疸的疗效观察[J].海峡药学，2017，29（1）：138.
[12] Nori M，Venkateshwarlu J，Vijaysekhar，et al. Extra hepatic biliary atresia with choledochal cyst：prenatal MRI predicted and post natally confirmed：a case report [J]. Indian J Radiol Imaging，2013，23（3）：238-242.
[13] 汤晶晶.茵栀黄颗粒联合蓝光治疗新生儿黄疸的临床效果观察与分析[J].中华全科医学，2015，13（4）：611-613.
[14] Qaisiya M，Coda Zabetta CD，Bellarosa C，et al. Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway [J]. Cell Signal，2013，26（3）：512-520.
[15] 朱晓萍，凌静，何晓英.腹部环形按摩联合扩肛法促进排便对新生儿黄疸的影响[J].护士进修杂志，2015，30（3）：278-279.
[16] Kale Y，Aydemir O，Celik U，et al. Effects of phototherapy using different light sources on oxidant and antioxidant status of neonates with jaundice [J]. Early Hum Dev，2013， 89（12）：957-960.
[17] 章历红，王丽莉，赵灵，等.妈咪爱联合蓝光照射早期干预对改善新生儿黄疸和生长发育的临床评估[J].中国妇幼保健，2015，30（23）：4036-4038.
[18] 何健，许英，陈俊杰.脐血胆红素检测在新生儿黄疸中的应用[J].国际检验医学杂志，2015，36（3）：409-410.
[19] 李举，郝晓广.蓝光联合茵栀黄颗粒治疗新生儿病理性黄疸临床疗效分析[J].中国生化药物杂志，2014，34（1）：121-122.
[20] 曹丽琴.血清白蛋白、非结合胆红素的检测在新生儿黄疸中的临床应用[J].中国现代医生，2015，53（2）：49-51.
[21] Yin J，Wennberg RP，Miller M. Induction of hepatic bilirubin and drug metabolizing enzymes by individual herbs present in the traditional Chinese medicine，yin zhi huang [J]. Dev Pharmacol Ther，1993，20（3/4）：186-194.
[22] 李邹金，冷秋文，唐清萍，等.妈咪爱散联合茵栀黄颗粒、思密达散干预新生儿黄疸的临床疗效观察[J].中国妇幼保健，2012，27（8）：1239-1240.
[23] 贾承英，崔彦敏，张青，等.不同蓝光照射方法联合妈咪爱治疗新生儿黄疸的效果观察[J].中国妇幼保健，2014， 29（15）：2358-2360.
2017, Vol. 14 
京公网安备 11010502046598号