Efficacy of different doses of Dexmedetomidine combined with Sufentanil for patient-controlled intravenous analgesia after spinal surgery
LIU Ying1 ZHANG Yunqiong1 ZHAO Zeyu2 WANG Zhongsheng1 GUO Yilin1
1.Department of Anesthesiology, Luzhou Hospital of Traditional Chinese Medicine, Sichuan Province, Luzhou 646000, China;
2.Department of Anesthesiology, Sichuan 81 Rehabilitation Center, Sichuan Province, Chengdu 611135, China
Abstract：Objective To evaluate the efficacy of different doses of Dexmedetomidine (Dex) combined with Sufentanil for patient-controlled intravenous analgesia after spinal surgery. Methods 120 cases of patients with ASA Ⅰ-Ⅲ grade underwent elective spinal surgery with general anesthesia in Luzhou Traditional Chinese Medicine Hospital from January 2015 to December 2016 were selected, and randomly divided into group A, group B and group C, each gorup had 40 cases. The postoperative intravenous analgesia formula: Sufentanil 0.05 μg/(kg·h) in group A, Sufentanil 0.03 μg/ (kg·h) + Dex 0.05 μg/(kg·h) in group B, and Sufentanil 0.03 μg/(kg·h) + Dex 0.08 μg/(kg·h) in group C, and all added to normal saline to 100 mL, loading dose of 3 mL, background dose of 2 mL/h, PCA dose of 1 mL and locking time of 15 min. The VAS and Ramsay scores at the time points of 2, 4, 6, 12, 24 h after surgery, PCIA pressing times, the dosages of Sufentanil and complications such as nausea and vomiting, hypotension, bradycardia, respiratory depression in the three groups were recorded. Results The VAS and Ramsay scores at different time points in the three groups were tatistically significant differences (P < 0.01). Compared with group A, the VAS scores at the time points of 4, 6, 12, 24 h after surgery in group B and group C were decreased (P < 0.01), and the VAS scores of group C were lower than those of group B (P < 0.05). Compared with group A, the Ramsay scores at the time points of 4, 6, 12, 24 h in group B and group C were increased (P < 0.05), and the Ramsay scores of group C were higher than those of group B (P < 0.05). The PCA pressing times and the dosage of Sufentanil of group B and group C were less than those of group A (P < 0.01), which of group C were less than those of group B（P < 0.01). The incidence of nausea and vomiting of group A was significantly higher than that of group B and group C (P < 0.05). Conclusion Dex combined with Sufentanil for patient-controlled intravenous analgesia after spinal surgery has good effects, and Dex can enhance the analgesic effect and reduce dosage and adverse reaction of opioids.
刘英1 张运琼1 赵泽宇2 王中胜1 郭屹霖1. 不同剂量右美托咪啶复合舒芬太尼用于脊柱手术后静脉自控镇痛的效果[J]. 中国医药导报, 2017, 14(19): 73-76.
LIU Ying1 ZHANG Yunqiong1 ZHAO Zeyu2 WANG Zhongsheng1 GUO Yilin1. Efficacy of different doses of Dexmedetomidine combined with Sufentanil for patient-controlled intravenous analgesia after spinal surgery. 中国医药导报, 2017, 14(19): 73-76.
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2017, Vol. 14 
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