Abstract：Objective To explore the influence of small doses of hormones on serum sTREM-1, PCT, CD64 in pediatric sepsis. Methods 66 cases of children with sepsis treated in Pediatrics Department of CNPC Central Hospital from March 2014 to March 2016 were selected as research objects. They were divided into two groups according to random number table method, 33 cases in each group. All pateints were given symptomatic treatment. Patients in the control group were given bundle of treatment, inculding antibiotics, intensive insulin, nutritional support. On the basis of the control gorup, patients in the study group were given small dose Methylprednisolone Sodium Succinate for Injection for 7 d. The levels of peripheral blood T lymphocyte, inflammatory index (PCT, CRP, IL-8) and sTREM-1, sICAM-1 and sVCAM-1 were detected. The scores of PCIS and APACHE Ⅱ were evaluated. The therapeutic effect was compared between the two groups. Results Compared with before treatment, after treatment two groups of CD3+, CD4+ and CD8+ increased (P < 0.01), CD64+ decreased (P < 0.01), levels of PCT, CRP, IL-8 decreased (P < 0.01), levels of sTREM -1, sICAM-1, sVCAM-1 decreased (P < 0.01), PCIS score increased (P < 0.01), APACHE Ⅱ score decreased (P < 0.01). Compared with the control group, the study group had higher CD3+, CD4+ and CD8+ (P < 0.01), lower CD64+ (P < 0.01), lower levels of PCT, CRP, IL-8 and sTREM-1、sICAM-1、sVCAM-1 (P < 0.01), higher PCIS score (P < 0.05), lower APACHE Ⅱ score (P < 0.01), and higher total effective rate (P < 0.05). Conclusion Small doses of glucocorticoid can effectively reduce serum sTREM-1, PCT, CD64+ levels of sepsis patients, which has important clinical value.
2017, Vol. 14 
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