柴石退热颗粒对流行性乙型脑炎病毒CQ11-66的影响

摘要
图/表
参考文献(19)
相关文章 (15)

全文: PDF (757 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨柴石退热颗粒对流行性乙型脑炎病毒CQ11-66的影响。方法选取2015年5月～2016年12月在河南省中医院住院的流行性乙型脑炎患者150例，按随机数字表法将其分为两组，各75例。对照组行常规综合治疗，观察组在对照组基础上加用柴石退热颗粒。两组均治疗15 d。治疗后观察两组临床疗效以及症状改善时间，比较两组患者住院时间以及治疗前后血清中神经元特异性烯醇化酶（NSE）、过氧化脂质（LPO）、白细胞介素-2（IL-2）含量。结果观察组痊愈率明显高于对照组，差异有统计学意义（P ＜ 0.05），观察组总有效率虽高于对照组，但差异无统计学意义（P ＞ 0.05）。观察组体温恢复正常时间、神智恢复正常时间及头痛、呕吐、抽搐缓解时间均明显短于对照组，差异均有统计学意义（P ＜ 0.05）。观察组平均住院时间明显短于对照组，差异有统计学意义（P ＜ 0.05）。治疗后，两组患者血清中NSE、LPO含量均明显低于治疗前，IL-2含量明显高于治疗前，差异均有统计学意义（P ＜ 0.05）。但两组治疗后血清中NSE、LPO、IL-2含量比较差异均无统计学意义（P ＞ 0.05）。结论柴石退热颗粒对流行性乙型脑炎病毒CQ11-66有明显的治疗效果，能够明显缩短患者住院时间，加快症状改善，有效减轻患者痛苦，值得广泛推广。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	刘志勇1 孟毅1 常学辉1 郭健1 乔明亮1 赵丽娜2

关键词 ：柴石退热颗粒, 流行性乙型脑炎病毒, CQ11-66, 疗效

Abstract：Objective To investigate the effects of Chaishi Tuire Granules on epidemic encephalitis B virus CQ11-66. Methods One hundred and fifty patients with epidemic encephalitis B hospitalized in He'nan Traditional Chinese Medicine Hospital from May 2015 to December 2016 were selected and divided into two groups by random number table method, with 75 cases in each group. The control group was treated with routine comprehensive treatment, on basis of control group, the observation group was added with Chaishi Tuire Granules. Both groups were treated for 15 days. After treatment, the clinical efficacy and symptom improvement time of the two groups were observed, the hospital stay and the contents of serum neuron-specific enolase (NSE), lipid peroxidase (LPO), interleukin-2 (IL-2) before and after treatment between the two groups were compared. Results The cure rate in the observation group was significantly higher than that in the control group, the difference was statistically significant (P ＜ 0.05), the total effective rate in the observation group was higher than that in the control group, but the difference was not statistically significant (P ＞ 0.05). The time of body temperature returned to normal, time of intelligence returned to normal, and the relief time of headache, vomiting, convulsions in the observation group was all shorter than those of control group, the differences were all statistically significant (P ＜ 0.05). The average hospital stay of observation group was shorter than that of control group, the difference was statistically significant (P ＜ 0.05). After treatment, the contents of serum NSE, LPO in the two groups were all lower than those before treatment, the contents of IL-2 were higher than those before treatment, the differences were all statistically significant (P ＜ 0.05). But there were no statistically significant differences of the contents of serum NSE, LPO, IL-2 after treatment between the two groups (P ＞ 0.05). Conclusion Chaishi Tuire Granules has obvious therapeutic effect for epidemic encephalitis B virus CQ11-66, which can obviously shorten hospital stay, speed up the improvement of symptoms, relieve the pain of patients effectively, it is worthy of extensive promotion.

Key words： Chaishi Tuire Granules Epidemic encephalitis B virus CQ11-66 Efficacy

基金资助:河南省科技攻关项目（142102310041）；
河南中医学院“博士科研基金”项目（BSJJ2014-20）。

通讯作者: 孟毅（1963.10-），男，教授，主任医师，博士研究生导师；研究方向：中医药防治脑血管疾病。

作者简介: 刘志勇（1979.1-），男，博士；研究方向：神经内科疾病教学与临床。

引用本文:

刘志勇1 孟毅1 常学辉1 郭健1 乔明亮1 赵丽娜2. 柴石退热颗粒对流行性乙型脑炎病毒CQ11-66的影响[J]. 中国医药导报, 2017, 14(16): 78-81.
LIU Zhiyong1 MENG Yi1 CHANG Xuehui1 GUO Jian1 QIAO Mingliang1 ZHAO Li'na2. Effects of Chaishi Tuire Granules on epidemic encephalitis B virus CQ11-66. 中国医药导报, 2017, 14(16): 78-81.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2017/V14/I16/78

[1] 承晓华，王诗远，刘元宝，等.流行性乙型脑炎减毒活疫苗加强免疫的Meta分析[J].中华疾病控制杂志，2016，20（7）：712-716.
[2] 中华人民共和国卫生部.流行性乙型脑炎诊断标准[S].北京：人民卫生出版社，2008：333-336.
[3] 中华人民共和国卫生部.中华人民共和国卫生行业标准[S].北京：人民卫生出版社，2008：360-366.
[4] 董梦久，李耘，刘志勇，等.中西医结合治疗流行性乙型脑炎临床观察[J].湖北中医药大学学报，2014，16（3）：66-68.
[5] Wang SY，Cheng XH，Li JX，et al. Comparing the immunogenicity and safety of 3 Japanese encephalitis vaccines in Asia-Pacific area：A systematic review and meta-analysis [J]. Hum Vaccin Immunother，2015，11（6）：1418-1425.
[6] Soumen R，Pratibha C，Abhay C. Evaluation of antiviral activity of essential oil of Trachyspermum Ammi against Japanese encephalitis virus [J]. Pharmacognosy Res，2015， 7（3）：263-267.
[7] Christa F，Bernd J. Product review on the JE vaccine IXIARO [J]. Hum Vaccin Immunother，2015，11（2）：411-420.
[8] Nimisha D，Sujita K，Hardeep M. Unfolding the mystery：rare presentation of Japanese encephalitis as catatonia [J]. Int J Nutr Pharmacol Neurol Dis，2015，5（4）：159-162.
[9] 张海燕，曹晗，王俊荣，等.乙型脑炎Vero细胞灭活疫苗毒株的遗传稳定性[J].中华实验和临床病毒学杂志，2014， 28（3）：191-193.
[10] Yin Z，Wang X，Li L，et al. Neurological sequelae of hospitalized Japanese encephalitis cases in Gansu province，China [J]. Am J Trop Med Hyg，2015，92（6）：77-83.
[11] Ji YK，Soo YP，Hey RL，et al. Extended stability of cyclin D1 contributes to limited cell cycle arrest at G1-phase in BHK-21 cells with Japanese encephalitis virus persistent infection [J]. J Microbiol，2015，53（1）：328-331. [12] Anit S，Monjori M，Gadey S，et al. A Japanese Encephalitis Vaccine From India Induces Durable and Cross-protective Immunity Against Temporally and Spatially Wide-ranging Global Field Strains [J]. J Infect Dis，2015，212（5）：715-725.
[13] 凃晋文，董梦久，刘志勇，等.清热解毒法治疗流行性乙型脑炎49例临床观察[J].光明中医，2012，27（10）：1979-1981.
[14] 牟艳杰，周小莉，董梦久，等.凃晋文教授辨治流行性乙型脑炎的学术经验[J].中华中医药杂志，2012，27（3）：639-641.
[15] 凃晋文，董梦久，刘志勇.清热解毒法治疗重型流行性乙型脑炎42例[J].中医研究，2012，25（8）：15-17.
[16] 李耘.流行性乙型脑炎中医证型与人基因多态性、相关细胞因子研究[D].武汉：湖北中医药大学，2014.
[17] Aleksandar S. Hom■opathie bei epidemischen Krankheiten [J]. AHZ，2015，260（6）：4-9.
[18] 杜松，彭鑫，李菲，等.60年中医治疗流行性乙型脑炎辨证分型概况分析[J].中国中医基础医学杂志，2014， 20（9）：1180-1183.
[19] 刘志勇.流行性乙型脑炎PCR检测病毒和中医证候特征研究[D].武汉：湖北中医药大学，2013.